Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles

	Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles
	Yan, Fei; Wu, Hao; Liu, Hongmei; Deng, Zhiting; Liu, Hong; Duan, Wanlu; Liu, Xin; Zheng, Hairong
刊名	JOURNAL OF CONTROLLED RELEASE
	2016
英文摘要	Multifunctional near-infrared (NIR) nanoparticles demonstrate great potential in tumor theranostic applications. To achieve the sensitive detection and effective phototherapy in the early stage of tumorgenesis, it is highly desirable to improve the targeting of NIR theranostic agents to biomarkers and to enhance their accumulation in tumor. Here we report a novel targeted multifunctional theranostic nanoparticle, internalized RGD (iRGD)modified indocyanine green (ICG) liposomes (iRGD-ICG-LPs), formolecular imaging-guided photothermal therapy (PTT) and photodynamic therapy (PDT) therapy againstbreast tumor. The iRGD peptides with high affinity to alpha v beta 3 integrin and effective tumor-internalized property were firstly used to synthesize iRGD-PEG(2000)-DSPE lipopeptides, which were further utilized to fabricate the targeted ICG liposomes. The results indicated that iRGD-ICG-LPs exhibited excellent stability and could provide an accurate and sensitive detection of breast tumor through NIR fluorescence molecularimaging. We further employed this nanoparticle for tumor theranostic application, demonstrating significantly higher tumor accumulation and tumor inhibition efficacy through PTT/PDT effects. Histological analysis further revealedmuchmore apoptotic cells, confirming the advantageous anti-tumor effect of iRGD-ICG-LPs over non-targeted ICG-LPs. Notably, the targeting therapy mediated by iRGD provides almost equivalent anti-tumor efficacy at a 12.5-fold lower drug dose than that by monoclonal antibody, and no tumorrecurrence and obvious treatment-induced toxicity were observed in our study. Our study provides a promising strategy to realize the sensitive detection and effective treatment of tumors by integratingmolecular imaging into PTT/PDT therapy.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0168365915303011
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10455]
专题	深圳先进技术研究院_医工所
作者单位	JOURNAL OF CONTROLLED RELEASE
推荐引用方式 GB/T 7714	Yan, Fei,Wu, Hao,Liu, Hongmei,et al. Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles[J]. JOURNAL OF CONTROLLED RELEASE,2016.
APA	Yan, Fei.,Wu, Hao.,Liu, Hongmei.,Deng, Zhiting.,Liu, Hong.,...&Zheng, Hairong.(2016).Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles.JOURNAL OF CONTROLLED RELEASE.
MLA	Yan, Fei,et al."Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles".JOURNAL OF CONTROLLED RELEASE (2016).