Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection

	Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection
	Zhang, Y.; Peng, B.; Wang, S.; Liang, Y.X.; Yang, J.; So, K.F.; Yuan, T.F.
刊名	Scientific Reports
	2016
英文摘要	Microglia are the mononuclear phagocytes with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection model of the retina, the retrograde degeneration of retinal ganglion cells induces microglial activations to a unique morphology termed rod microglia. A few studies described the rod microglia in the cortex and retina; however, the spatial characteristic of rod microglia is not fully understood. In this study, we built a mathematical model to characterize the spatial trait of rod microglia. In addition, we developed a Matlab-based image processing pipeline that consists of log enhancement, image segmentation, mathematical morphology based cell detection, area calculation and angle analysis. This computer program provides researchers a powerful tool to quickly analyze the spatial trait of rod microglia.
收录类别	SCI
原文出处	http://www.nature.com/articles/srep21816
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10441]
专题	深圳先进技术研究院_医工所
作者单位	Scientific Reports
推荐引用方式 GB/T 7714	Zhang, Y.,Peng, B.,Wang, S.,et al. Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection[J]. Scientific Reports,2016.
APA	Zhang, Y..,Peng, B..,Wang, S..,Liang, Y.X..,Yang, J..,...&Yuan, T.F..(2016).Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection.Scientific Reports.
MLA	Zhang, Y.,et al."Image processing methods to elucidate spatial characteristics of retinal microglia after opticnerve transection".Scientific Reports (2016).