Alterations in regional homogeneity of resting:state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)

	Alterations in regional homogeneity of resting:state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)
	Yang, Haichen; Li, Linling; Peng, Hongjun; Liu, Tiebang; Young, Allan H; Angst, Jules; Ye, Rong; Rong, Han; Ji, Erni; Qiu, Yunhai
刊名	JOURNAL OF AFFECTIVE DISORDERS
	2016
英文摘要	Background: Bipolar disorder (BD) is difficult to diagnose in the early stages of the illness, with the most frequent misdiagnosis being major depressive disorder (MDD). We aimed to use a regional homogeneity (ReHo) approach with resting-state functional magnetic resonance imaging (rs-fMRI) to investigate the features of spontaneous brain activity in MDD patients screening positive on the 32-item Hypomania Checklist (HCL-32). Methods: Nineteen MDD patients screening positive (HCL-32(+); 9 males; 24.9 +/- 5.7 years) and 18 patients screening negative (HCL-32(-); 9 males; 27.1 +/- 6.7 years), together with 24 healthy controls (HC; 11 males; 26.4 +/- 3.9 years) were studied. ReHo maps were compared and an receiver operating characteristic (ROC) analysis was conducted to confirm the utility of the identified ReHo differences in classifying the patients. Results: The MDD versus HC showed different ReHo in many brain areas, especially in the frontal and parietal cortex. The HCL-32(+) versus HCL-32(-) showed significant increase of ReHo in the right medial superior frontal cortex, left inferior parietal cortex and middle/inferior temporal cortex, and decrease of ReHo in the left postcentral cortex and cerebellum. ROC analysis showed good sensitivity and specificity for distinguishing these two subgroups of MDD. Limitations: Recruited patients were all on antidepressants and standard mania rating scales were not performed to assess their hypomanic symptoms. Conclusions: The rs-fMRI measurement of ReHo in distributed brain regions may be putative biomarkerg which could differentiate subthreshold BD from MDD. (C) 2016 Elsevier B.V. All rights reserved.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0165032715309800
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10369]
专题	深圳先进技术研究院_医工所
作者单位	JOURNAL OF AFFECTIVE DISORDERS
推荐引用方式 GB/T 7714	Yang, Haichen,Li, Linling,Peng, Hongjun,et al. Alterations in regional homogeneity of resting:state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)[J]. JOURNAL OF AFFECTIVE DISORDERS,2016.
APA	Yang, Haichen.,Li, Linling.,Peng, Hongjun.,Liu, Tiebang.,Young, Allan H.,...&Li, Lingjiang.(2016).Alterations in regional homogeneity of resting:state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32).JOURNAL OF AFFECTIVE DISORDERS.
MLA	Yang, Haichen,et al."Alterations in regional homogeneity of resting:state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)".JOURNAL OF AFFECTIVE DISORDERS (2016).