Placebo Analgesia Changes Alpha Oscillations Induced by Tonic Muscle Pain: EEG Frequency Analysis Including Data during Pain Evaluation

	Placebo Analgesia Changes Alpha Oscillations Induced by Tonic Muscle Pain: EEG Frequency Analysis Including Data during Pain Evaluation
	Li, Linling; Wang, Hui; Ke, Xijie; Liu, Xiaowu; Yuan, Yuan; Zhang, Deren; Xiong, Donglin; Qiu, Yunhai
刊名	FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
	2016
英文摘要	Placebo exhibits beneficial effects on pain perception in human experimental studies. Most of these studies demonstrate that placebo significantly decreased neural activities in pain modulatory brain regions and pain-evoked potentials. This study examined placebo analgesia-related effects on spontaneous brain oscillations. We examined placebo effects on four order-fixed 20-min conditions in two sessions: isotonic saline-inducedcontrol conditions (with/without placebo) followed by hypertonic saline-induced tonic muscle pain conditions (with/without placebo) in 19 subjects using continuous electroencephalography (EEG) recording. Placebotreatment exerted significant analgesic effects in 14 placebo responders, as subjective intensity of painperception decreased. Frequency analyses were performed on whole continuous EEG data, data duringpain perception rating and data after rating. The results in the first two cases revealed that placebo inducedsignificant increases and a trend toward significant increases in the amplitude of alpha oscillation duringtonic muscle pain compared to control conditions in frontal-central regions of the brain, respectively.Placebo-induced decreases in the subjective intensity of pain perception significantly and positively correlated with the increases in the amplitude of alpha oscillations during pain conditions. In conclusion, the modulation effect of placebo treatment was captured when the pain perception evaluating period was included. The strong correlation between the placebo effect on reported pain perception and alpha amplitude suggest that alpha oscillations in frontal-central regions serve as a cortical oscillatory basis of the placeboeffect on tonic muscle pain. These results provide important evidence for the investigation of objective indicators of the placebo effect.
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861840/
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10359]
专题	深圳先进技术研究院_医工所
作者单位	FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
推荐引用方式 GB/T 7714	Li, Linling,Wang, Hui,Ke, Xijie,et al. Placebo Analgesia Changes Alpha Oscillations Induced by Tonic Muscle Pain: EEG Frequency Analysis Including Data during Pain Evaluation[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,2016.
APA	Li, Linling.,Wang, Hui.,Ke, Xijie.,Liu, Xiaowu.,Yuan, Yuan.,...&Qiu, Yunhai.(2016).Placebo Analgesia Changes Alpha Oscillations Induced by Tonic Muscle Pain: EEG Frequency Analysis Including Data during Pain Evaluation.FRONTIERS IN COMPUTATIONAL NEUROSCIENCE.
MLA	Li, Linling,et al."Placebo Analgesia Changes Alpha Oscillations Induced by Tonic Muscle Pain: EEG Frequency Analysis Including Data during Pain Evaluation".FRONTIERS IN COMPUTATIONAL NEUROSCIENCE (2016).