Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments

	Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments
	Xin-Hui Xie; Xin-Luan Wang; Hui-Lin Yang; De-Wei; Ling Qin.
刊名	Journal of Orthopaedic Translation
	2015
英文摘要	Steroid-associated osteonecrosis (SAON) is a common orthopaedic problem caused by administration of corticosteroids prescribed for many nonorthopaedic medical conditions. We summarised different pathophysiologies of SAON which have adverse effects on multiple systems such as bone marrow stem cells (BMSCs) pool, bone matrix, cell apoptosis, lipid metabolism, and angiogenesis. Different animal models were introduced to mimic the pathophysiology of SAON and for testing the efficacy of both prevention and treatment effects of various chemical drugs, biological, and physical therapies. According to the classification of SAON, several prevention and treatment methods are applied at the different stages of SAON. For the current period, Chinese herbs may also have the potential to prevent the occurrence of SAON. In the future, genetic analysis might also be helpful to effectively predict the development of ON and provide information for personalised prevention and treatment of patients with SAON.
收录类别	其他
原文出处	http://www.sciencedirect.com/science/article/pii/S2214031X14002575
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7181]
专题	深圳先进技术研究院_医工所
作者单位	Journal of Orthopaedic Translation
推荐引用方式 GB/T 7714	Xin-Hui Xie,Xin-Luan Wang,Hui-Lin Yang,et al. Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments[J]. Journal of Orthopaedic Translation,2015.
APA	Xin-Hui Xie,Xin-Luan Wang,Hui-Lin Yang,De-Wei,&Ling Qin..(2015).Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments.Journal of Orthopaedic Translation.
MLA	Xin-Hui Xie,et al."Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments".Journal of Orthopaedic Translation (2015).