High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter

	High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter
	Yan Li; Xiaojing Gong; Chengbo Liu; Riqiang Lin; William Hau; Xiaosong Bai; Liang Song
刊名	JOURNAL OF BIOMEDICAL OPTICS
	2015
英文摘要	Intravascular spectroscopic photoacoustic technology can image atherosclerotic plaque composition with high sensitivity and specificity, which is critical for identifying vulnerable plaques. Here, we designed and engineered a catheter of 0.9 mm in diameter for intravascular photoacoustic (IVPA) imaging, smaller than the critical size of 1 mm required for clinical translation. Further, a quasifocusing photoacoustic excitation scheme was developed for thecatheter, producing well-detectable IVPA signals from stents and lipids with a laser energy as low as similar to 30 mu J/pulse. As a result, this design enabled the use of a low-energy, high-repetition rate, ns-pulsed optical parametric oscillator laser for high-speed spectroscopic IVPA imaging at both the 1.2-mu m and 1.7-mu m spectral bands for lipid detection. Specifically, for each wavelength, a 1-kHz IVPA A-line rate was achieved, similar to 100-fold faster than previously reported IVPA systems offering a similar wavelength tuning range. Using the system, spectroscopic IVPA imaging of peri-adventitial adipose tissue from a porcine aorta segment was demonstrated. The significantly improved imaging speed, together with the reduced cathetersize and multi-wavelength spectroscopic imaging ability, suggests that the developed high-speed IVPA technology is of great potential to be further translated for in vivo applications. (
收录类别	SCI
原文出处	http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=2352820
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7069]
专题	深圳先进技术研究院_医工所
作者单位	JOURNAL OF BIOMEDICAL OPTICS
推荐引用方式 GB/T 7714	Yan Li,Xiaojing Gong,Chengbo Liu,et al. High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter[J]. JOURNAL OF BIOMEDICAL OPTICS,2015.
APA	Yan Li.,Xiaojing Gong.,Chengbo Liu.,Riqiang Lin.,William Hau.,...&Liang Song.(2015).High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter.JOURNAL OF BIOMEDICAL OPTICS.
MLA	Yan Li,et al."High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter".JOURNAL OF BIOMEDICAL OPTICS (2015).