A Facile Synthesis of Versatile Cu2-xS Nanoprobe for Enhanced MRI and Infrared Thermal/Photoacoustic Multimodal Imaging

	A Facile Synthesis of Versatile Cu2-xS Nanoprobe for Enhanced MRI and Infrared Thermal/Photoacoustic Multimodal Imaging
	J. Mou; C. Liu; P. Li; Y. Chen; H. Xu; C. Wei; L. Song; J. Shi; H. Chen
刊名	Biomaterials
	2015
英文摘要	A novel type of intelligent nanoprobe by using single component of Cu2_xS for multimodal imaging has been facilely and rapidly synthesized in scale via thermal decomposition followed by biomimetic phospholipid modification, which endows them with uniform and small nanoparticle size (ca.15 nm), well phosphate buffer saline (PBS) dispersity, high stability, and excellent biocompatibility. The assynthesized Cu2_xS nanoprobes (Cu2_xS NPs) are capable of providing contrast enhancement for T1-weighted magnetic resonance imaging (MRI), as demonstrated by the both in vitro and in vivo imaging investigations for the first time. In addition, due to their strong near infrared (NIR) optical absorption, they can also serve as a candidate contrast agent for enhanced infrared thermal/photoacoustic imaging, to meet the shortfalls of MRI. Hence, complementary and potentially more comprehensive information can be acquired for the early detection and accurate diagnosis of cancer. Furthermore, negligible systematic side effects to the blood and tissue were observed in a relatively long period of 3 months. The distinctive multimodal imaging capability with excellent hemo/histocompatibility of the Cu2_xS NPs could open up a new molecular imaging possibility for detecting and diagnosing cancer or other diseases in the future.
收录类别	SCI
原文出处	www.sciencedirect.com/science/article/pii/S0142961215003671
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7064]
专题	深圳先进技术研究院_医工所
作者单位	Biomaterials
推荐引用方式 GB/T 7714	J. Mou,C. Liu,P. Li,et al. A Facile Synthesis of Versatile Cu2-xS Nanoprobe for Enhanced MRI and Infrared Thermal/Photoacoustic Multimodal Imaging[J]. Biomaterials,2015.
APA	J. Mou.,C. Liu.,P. Li.,Y. Chen.,H. Xu.,...&H. Chen.(2015).A Facile Synthesis of Versatile Cu2-xS Nanoprobe for Enhanced MRI and Infrared Thermal/Photoacoustic Multimodal Imaging.Biomaterials.
MLA	J. Mou,et al."A Facile Synthesis of Versatile Cu2-xS Nanoprobe for Enhanced MRI and Infrared Thermal/Photoacoustic Multimodal Imaging".Biomaterials (2015).