Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21

	Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21
	Yiping Hu; Ruoxi Liu; Jinchao Li; Ye Yue; Wenxiang Cheng; Peng Zhang
刊名	BIOMED RESEARCH INTERNATIONAL
	2014
英文摘要	This research was performed to observe the effect of GTS-21 on Collagen Induced Arthritis (CIA). CIA model was used and after the onset of arthritis, the rats were divided into three groups based on their clinical symptoms score. Two groups were intraperitoneally (IP) injected daily with GTS-21 (1 mg/kg, 2.5 mg/kg) for a week, whereas phosphate buffered saline (PBS) was used for the control group. Cytokine titers, radiological, and histological examinations were performed at different time points after treatment with GTS-21. Compared with those of the control, the levels of TNF-alpha, IL-1, and IL-6 in the serum were significantly reduced after GTS-21 management. In addition, radiological results show that bone degradation was inhibited as well. Moreover, the hematoxylin and eosin (H&E) staining indicated that the histological score was significantly alleviated in the therapeutic group. Tartrate-resistant acid phosphatase (TRAP) stain-positive cells were also detected in the destruction of the articular cartilage, which was significantly reduced compared with the control group. This study provides the first evidence on the effect of GTS-21 as a potential treatment for RA.
收录类别	SCI
原文出处	http://www.hindawi.com/journals/bmri/2014/325875/
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5838]
专题	深圳先进技术研究院_医工所
作者单位	BIOMED RESEARCH INTERNATIONAL
推荐引用方式 GB/T 7714	Yiping Hu,Ruoxi Liu,Jinchao Li,et al. Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21[J]. BIOMED RESEARCH INTERNATIONAL,2014.
APA	Yiping Hu,Ruoxi Liu,Jinchao Li,Ye Yue,Wenxiang Cheng,&Peng Zhang.(2014).Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21.BIOMED RESEARCH INTERNATIONAL.
MLA	Yiping Hu,et al."Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21".BIOMED RESEARCH INTERNATIONAL (2014).