COMPARATIVE STUDY OF TWO TYPES OF BIOACTIVE EPIMEDIUM FOR OSTEOPOROSISTREATMENT IN OVARIECTOMIZED RAT MODEL

	COMPARATIVE STUDY OF TWO TYPES OF BIOACTIVE EPIMEDIUM FOR OSTEOPOROSISTREATMENT IN OVARIECTOMIZED RAT MODEL
	Chen S.; Wang X.; Bai Y.; Zheng L.; Qin L.
刊名	OSTEOPOROSIS INTERNATIONAL
	2013
英文摘要	Background: Osteoporosis is a systemic metabolic disease causing a reduction of bone mass and strength, and an increase infracture risk consequently. Traditional Chinese Herbs, e.g. Epimedium are often used as a major composition to formulate herbal formula for osteoporosis treatment. Different locality of herbs may cause different properties that would be a decision of herbal formula selection for R&D of anti-osteoporosis herbal drugs. This study aims to compare the efficacy of two Epimedium species, namely Epimedium koreanum Nakai (X1) and Epimedium pubescens Maxim (X2). Methods: Ovariectomized (OVX) model was established in sixty female Sprague Dawley rats (220±20g). High (90 mg/kg/day) and low (45 mg/kg/day) dosages of X1 and X2 were designed for daily intragastric administration for 90 days post OVX, namely X1L, X1H, X2L and X2H groups, also sham-operated rats (sham group) and OVX rats (OVX group). After scarifying the animals, micro-CT scanning of the proximal tibia and the fourth lumbar vertebra was conducted for evaluations of bone mineral density (BMD), bone tissue volume fraction (BV/TV) and trabecular number (Tb. N). Biomechanical properties of the mid-shaft of tibia and the fourth lumbar vertebra were also obtained. Results: Micro-CT results of proximal tibia showed that as compared to OVX group, significant higher BMD (28.41% and 25.35%) and BV/TV (33.01% and 38.33%) were found in X1H and X2L groups, respectively (p<0.05, n=8). For micro-CT results of vertebra, significant higher BMD (23.72% and 22.90%), BV/TV (31.70% and 30.96%) and Tb.N (26.85% and 18.27%) were presented in X1H and X2L groups, respectively (p<0.05, n=8). Based on the results of 3-point bending test in tibia, there was no significant difference of the mechanical strength between OVX group and each Epimedium groups (p>0.05, n=8), however, the results of compression test indicated the significant higher E-Modulus (81.82%, 80.21% and 72.04%) and compressive strength (74.59%, 64.92% and 81.05%) in X1L, X1H and X2L groups, respectively (p<0.05, n=8). Conclusion: The two species of Epimedium showed significant efficacy for slowing the loss of bone mass and strength in osteoporosis, which presented a potential dose effect for both of the two species. However, there was no significant difference found between the high dose of X1 and low dose of X2, which indicated that both two Epimedium species could be selected for R&D of herbal drug.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S2214031X1400148X
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4912]
专题	深圳先进技术研究院_医工所
作者单位	OSTEOPOROSIS INTERNATIONAL
推荐引用方式 GB/T 7714	Chen S.,Wang X.,Bai Y.,et al. COMPARATIVE STUDY OF TWO TYPES OF BIOACTIVE EPIMEDIUM FOR OSTEOPOROSISTREATMENT IN OVARIECTOMIZED RAT MODEL[J]. OSTEOPOROSIS INTERNATIONAL,2013.
APA	Chen S.,Wang X.,Bai Y.,Zheng L.,&Qin L..(2013).COMPARATIVE STUDY OF TWO TYPES OF BIOACTIVE EPIMEDIUM FOR OSTEOPOROSISTREATMENT IN OVARIECTOMIZED RAT MODEL.OSTEOPOROSIS INTERNATIONAL.
MLA	Chen S.,et al."COMPARATIVE STUDY OF TWO TYPES OF BIOACTIVE EPIMEDIUM FOR OSTEOPOROSISTREATMENT IN OVARIECTOMIZED RAT MODEL".OSTEOPOROSIS INTERNATIONAL (2013).