Stimulated Angiogenesis for Fracture Healing Augmented by Low-Magnitude, High-Frequency Vibration in A Rat Model-Evaluation of Pulsed-Wave Doppler, 3-D Power Doppler Ultrasonography and Micro-CT Microangiography

	Stimulated Angiogenesis for Fracture Healing Augmented by Low-Magnitude, High-Frequency Vibration in A Rat Model-Evaluation of Pulsed-Wave Doppler, 3-D Power Doppler Ultrasonography and Micro-CT Microangiography
	WING-HOI CHEUNG; MING-HUI SUN; YONG-PING ZHENG; WINNIE CHIU-WING CHU; ANDRAAY HON-CHI LEUNG; LING QIN; FANG-YUAN WEI; KWOK-SUI LEUNG
刊名	ULTRASOUND IN MEDICINE AND BIOLOGY
	2012
英文摘要	This study aimed to investigate the mechanism of low-magnitude high-frequency vibration (LMHFV) treatment on angiogenesis and blood flow for enhancement of fracture healing. Nine-month-old ovariectomized (OVX) and sham-operated (Sham) rats received closed fractures creation at the femora and were randomized into LMHFV treatment (Sham-V, OVX-V) or control (Sham-C, OVX-C) groups. Pulsed-wave Doppler indicated an increase in blood flow velocity of the femoral artery at weeks 2 (OVX pair: p = 0.030) and 4 (OVX pair: p = 0.012; Sham pair: p = 0.020) post-treatment. Significantly enhanced vascular volume (VV) at the fracture site in the vibration groups was demonstrated by 3-D high-frequency power Doppler at week 2 (Sham pair: p = 0.021) and micro-computed tomography (microCT) microangiography at weeks 2 (OVX pair: p = 0.009) and 4 (OVX pair: p = 0.034), which echoed the osteogenesis findings by radiographic and microCT analysis. VV in the OVX groups was inferior to the Sham groups. However, OVX-V showed higher percentages of angiogenic enhancement than Sham-V. Despite impaired neo-angiogenesis in osteoporotic fractures, LMHFV could increase blood flow and angiogenesis in both normal and osteoporotic fractures, thus enhancing fracture healing.
收录类别	SCI
原文出处	http://ac.els-cdn.com/S0301562912004425/1-s2.0-S0301562912004425-main.pdf?_tid=9c733e66-0947-11e5-a9c8-00000aacb35d&acdnat=1433264067_6c386695d2bb86c1329001b7b718e0db
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4030]
专题	深圳先进技术研究院_医工所
作者单位	ULTRASOUND IN MEDICINE AND BIOLOGY
推荐引用方式 GB/T 7714	WING-HOI CHEUNG,MING-HUI SUN,YONG-PING ZHENG,et al. Stimulated Angiogenesis for Fracture Healing Augmented by Low-Magnitude, High-Frequency Vibration in A Rat Model-Evaluation of Pulsed-Wave Doppler, 3-D Power Doppler Ultrasonography and Micro-CT Microangiography[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2012.
APA	WING-HOI CHEUNG.,MING-HUI SUN.,YONG-PING ZHENG.,WINNIE CHIU-WING CHU.,ANDRAAY HON-CHI LEUNG.,...&KWOK-SUI LEUNG.(2012).Stimulated Angiogenesis for Fracture Healing Augmented by Low-Magnitude, High-Frequency Vibration in A Rat Model-Evaluation of Pulsed-Wave Doppler, 3-D Power Doppler Ultrasonography and Micro-CT Microangiography.ULTRASOUND IN MEDICINE AND BIOLOGY.
MLA	WING-HOI CHEUNG,et al."Stimulated Angiogenesis for Fracture Healing Augmented by Low-Magnitude, High-Frequency Vibration in A Rat Model-Evaluation of Pulsed-Wave Doppler, 3-D Power Doppler Ultrasonography and Micro-CT Microangiography".ULTRASOUND IN MEDICINE AND BIOLOGY (2012).