Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function

	Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function
	Zhe Yu; Timothy E. McKnight; M. Nance Ericson; Anatoli V. Melechko; Michael L. Simpson; Barclay Morrison III
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2012
英文摘要	Neural chips, which are capable of simultaneous multisite neural recording and stimulation, have been used to detect and modulate neural activity for almost thirty years. As neural interfaces, neural chips provide dynamic functional information for neural decoding and neural control. By improving sensitivity and spatial resolution, nano-scale electrodes may revolutionize neural detection and modulation at cellular and molecular levels as nano-neuron interfaces. We developed a carbon-nanofiber neural chip with lithographically defined arrays of vertically aligned carbon nanofiber electrodes and demonstrated its capability of both stimulating and monitoring electrophysiological signals from brain tissues in vitro and monitoring dynamic information of neuroplasticity. This novel nano-neuron interface may potentially serve as a precise, informative, biocompatible, and dual-mode neural interface for monitoring of both neuroelectrical and neurochemical activity at the single-cell level and even inside the cell. From the Clinical Editor: The authors demonstrate the utility of a neural chip with lithographically defined arrays of vertically aligned carbon nanofiber electrodes. The new device can be used to stimulate and/or monitor signals from brain tissue in vitro and for monitoring dynamic information of neuroplasticity both intracellularly and at the single cell level including neuroelectrical and neurochemical activities. (C) 2012 Elsevier Inc. All rights reserved.
收录类别	SCI
原文出处	http://ac.els-cdn.com/S1549963412000871/1-s2.0-S1549963412000871-main.pdf?_tid=fc7102b4-0864-11e5-946c-00000aab0f27&acdnat=1433166733_171e5c07bc37950a9a7b6b9073ae038f
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/3976]
专题	深圳先进技术研究院_医工所
作者单位	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
推荐引用方式 GB/T 7714	Zhe Yu,Timothy E. McKnight,M. Nance Ericson,et al. Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2012.
APA	Zhe Yu,Timothy E. McKnight,M. Nance Ericson,Anatoli V. Melechko,Michael L. Simpson,&Barclay Morrison III.(2012).Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.
MLA	Zhe Yu,et al."Vertically aligned carbon nanofiber as nano-neuron interface for monitoring neural function".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012).