Using optogenetics to translate the“inflammatory dialogue” between heart and brain in the context of stress

	Using optogenetics to translate the“inflammatory dialogue” between heart and brain in the context of stress
	Jinbo Cheng; Jie Zhang; Caiyi Lu; Liping Wang
刊名	NEUROSCIENCE BULLETIN
	2012
英文摘要	Inflammatory processes are an integral part of the stress response and are likely to result from a programmed adaptation that is vital to the organism's survival and well-being. The whole inflammatory response is mediated by largely overlapping circuits in the limbic forebrain, hypothalamus and brainstem, but is also under the control of the neuroendocrine and autonomic nervous systems. Genetically predisposed individuals who fail to tune the respective contributions of the two systems in accordance with stressor modality and intensity after adverse experiences can be at risk for stress-related psychiatric disorders and cardiovascular diseases. Altered glucocorticoid (GC) homeostasis due to GC resistance leads to the failure of neural and negative feedback regulation of the hypothalamic-pituitary-adrenal axis during chronic inflammation, and this might be the mechanism underlying the ensuing brain and heart diseases and the high prevalence of co-morbidity between the two systems. By the combined use of light and genetically-encoded light-sensitive proteins, optogenetics allows cell-type-specific, fast (millisecond-scale) control of precisely defined events in biological systems. This method is an important breakthrough to explore the causality between neural activity patterns and behavioral profiles relevant to anxiety, depression, autism and schizophrenia. Optogenetics also helps to understand the "inflammatory dialogue", the inflammatory processes in psychiatric disorders and cardiovascular diseases, shared by heart and brain in the context of stress.
收录类别	SCI
原文出处	http://download.springer.com/static/pdf/798/art%253A10.1007%252Fs12264-012-1246-2.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs12264-012-1246-2&token2=exp=1433164983~acl=%2Fstatic%2Fpdf%2F798%2Fart%25253A10.1007%25252Fs12264-012-1246-2.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs12264-012-1246-2*~hmac=d89d9973a24e9491c507eba3e2614e0bee45f5b67f8e816ccf4c995bff80de91
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/3969]
专题	深圳先进技术研究院_医工所
作者单位	NEUROSCIENCE BULLETIN
推荐引用方式 GB/T 7714	Jinbo Cheng,Jie Zhang,Caiyi Lu,et al. Using optogenetics to translate the“inflammatory dialogue” between heart and brain in the context of stress[J]. NEUROSCIENCE BULLETIN,2012.
APA	Jinbo Cheng,Jie Zhang,Caiyi Lu,&Liping Wang.(2012).Using optogenetics to translate the“inflammatory dialogue” between heart and brain in the context of stress.NEUROSCIENCE BULLETIN.
MLA	Jinbo Cheng,et al."Using optogenetics to translate the“inflammatory dialogue” between heart and brain in the context of stress".NEUROSCIENCE BULLETIN (2012).