Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis

	Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis
	Yuan Wu; Li-Ping Wang; Jian-Qing Pan
刊名	MEDICAL HYPOTHESES
	2011
卷号	77 期号:5 页码:745-777
英文摘要	Endometriosis (EMs) is defined as the presence of tissue which somewhat resembles endometrial glands and stroma outside the uterus, and elicit an inflammatory response. This response is accompanied by angiogenesis, adhesions, fibrosis, scarring, neuronal infiltration, and anatomical distortion, resulting in pain and infertility. Owing to the side effects of the present medical treatment and the 10% incidence of recurrence after surgery, EMs is difficult to cure completely so far, that have given impetus to consider novel therapy. Since 1980s, cigarette smoking was found inversely related to the risk of having EMs and it is generally considered that nicotine may play a beneficial role in the pathological process of EMs. Recently, the anti-inflammatory and anti-nociceptive functions of nicotinic acetylcholine receptors (nAChRs) as well as the related mechanisms have become a research hotspot. Based on the above-mentioned, it suggests that the nicotinic acetylcholine receptor agonists may be applied for the treatment of EMs.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S030698771100346X
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/3469]
专题	深圳先进技术研究院_医工所
作者单位	MEDICAL HYPOTHESES
推荐引用方式 GB/T 7714	Yuan Wu,Li-Ping Wang,Jian-Qing Pan. Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis[J]. MEDICAL HYPOTHESES,2011,77(5):745-777.
APA	Yuan Wu,Li-Ping Wang,&Jian-Qing Pan.(2011).Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis.MEDICAL HYPOTHESES,77(5),745-777.
MLA	Yuan Wu,et al."Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis".MEDICAL HYPOTHESES 77.5(2011):745-777.