Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics

	Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics
	Chunxiang Jiang; Xiang Li; Fei Yan; Zhanhui Wang; Qiaofeng Jin; Feiyan Cai; Ming Qian; Xin Liu; Lijuan Zhang; Hairong Zheng
刊名	MICRO & NANO LETTERS
	2011
卷号	6 期号:6 页码:417-21
英文摘要	Microbubbles (MBs) coated by surfactant or polymer have been shown to be the most effective contrast agents for diagnostic ultrasound contrast imaging and targeted molecular imaging. With the development of both diagnostic and therapeutic applications of ultrasound contrast agents (UCAs), there is a demand for new preparation technologies to provide a high degree of control over MB size, composition, stability and uniformity in response. MBs produced by traditional methods, such as sonication or mechanical agitation, have poor control over MBs' size and uniformity. A polydisperse size distribution may have the inherent limitation of low acoustic backscattering efficiency and uncontrollable safety concern if used in vivo. This study presents successful production of five kinds of monodisperse MBs by flow-focusing method based on four flow-focusing units integrated microfluidic devices. These MBs act as a vehicle to carry fluorescent probe 6-coumarin, tumour-targeted peptide (LyP-1), paclitaxel, superparamagnetic iron oxide Fe3O4 nanoparticles and CdTe/ZnS quantum dots in the lipid shells, respectively. The sizes of MBs are controlled on the order of 2-7 μm by adjusting gas pressure and liquid flow velocity. These functional MBs have the potential applications in emerging areas, such as drug delivery, ultrasound molecular imaging and dual-modality imaging.
收录类别	SCI
原文出处	http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=5960462&tag=1
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/3443]
专题	深圳先进技术研究院_医工所
作者单位	MICRO & NANO LETTERS
推荐引用方式 GB/T 7714	Chunxiang Jiang,Xiang Li,Fei Yan,et al. Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics[J]. MICRO & NANO LETTERS,2011,6(6):417-21.
APA	Chunxiang Jiang.,Xiang Li.,Fei Yan.,Zhanhui Wang.,Qiaofeng Jin.,...&Hairong Zheng.(2011).Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics.MICRO & NANO LETTERS,6(6),417-21.
MLA	Chunxiang Jiang,et al."Microfluidic-assisted formation of multifunctional monodisperse microbubbles for diagnostics and therapeutics".MICRO & NANO LETTERS 6.6(2011):417-21.