Potential Use of Erythromycin to Prevent and Treat Prosthetic Failure

	Potential Use of Erythromycin to Prevent and Treat Prosthetic Failure
	Peng Zhang; Ling Qin
刊名	JOURNAL OF CLINICAL PHARMACOLOGY
	2010
卷号	50 期号:8 页码:858-860
英文摘要	Prolonged prosthetic life span is a goal that orthopedic surgeons are pursuing. Both septic and aseptic loosening may lead to prosthetic failure. For decades, antibiotics have been applied in arthroplasty to prevent septic loosening, with excellent clinical results, although few therapies have been able to prevent aseptic loosening. Research on aseptic loosening indicates that osteoclasts play an essential role in this process. Thus, the exploration of osteoclastogenesis inhibitor has become of interest. Erythromycin is a broad-spectrum antimicrobial that has been used to prevent postoperative infection after artificial joint replacement. A new function to inhibit particle-induced osteolysis has been discovered recently. Fundamental research indicates that erythromycin administration should be an excellent method for the prophylaxis of prosthetic failure and should increase the life span of artificial joint in clinics.
收录类别	SCI
原文出处	http://onlinelibrary.wiley.com/doi/10.1177/0091270009360535/epdf
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/2974]
专题	深圳先进技术研究院_医工所
作者单位	JOURNAL OF CLINICAL PHARMACOLOGY
推荐引用方式 GB/T 7714	Peng Zhang,Ling Qin. Potential Use of Erythromycin to Prevent and Treat Prosthetic Failure[J]. JOURNAL OF CLINICAL PHARMACOLOGY,2010,50(8):858-860.
APA	Peng Zhang,&Ling Qin.(2010).Potential Use of Erythromycin to Prevent and Treat Prosthetic Failure.JOURNAL OF CLINICAL PHARMACOLOGY,50(8),858-860.
MLA	Peng Zhang,et al."Potential Use of Erythromycin to Prevent and Treat Prosthetic Failure".JOURNAL OF CLINICAL PHARMACOLOGY 50.8(2010):858-860.