Impact of reduction in early- and late-systolic functional mitral regurgitation on reverse remodeling after cardiac resynchronization therapy

	Impact of reduction in early- and late-systolic functional mitral regurgitation on reverse remodeling after cardiac resynchronization therapy
	Yu-Jia Liang; Qing Zhang; Jeffrey Wing-Hong Fung; Joseph Yat-Sun Chan; Gabriel Wai-Kwok Yip; Yat-Yin Lam; Cheuk-Man Yu
刊名	EUROPEAN HEART JOURNAL
	2010
卷号	31 期号:19 页码:2359-2368
英文摘要	To examine whether the presence of pre-pacing functional mitral regurgitation (MR) and its improvement would affect the extent of left ventricular (LV) reverse remodelling after cardiac resynchronization therapy (CRT). Echocardiographic assessment was performed in 83 patients before and 3 months after CRT. Total MR volume and the early- and late-systolic MR flow rate were assessed. At 3 months, there was reduction in total MR volume (38 +/- 20 vs. 33 +/- 21 mL) with decrease in both early- (71 +/- 52 vs. 60 +/- 51 mL/s) and late-systolic (49 +/- 46 vs. 42 +/- 46 mL/s) MR flow rate (all P < 0.05). Receiver-operating characteristic curve found that an 11% decrease in total MR volume was associated with LV reverse remodelling [defined by the reduction in LV end-systolic volume (LVESV) of >= 15%] [sensitivity, 90%; specificity, 80%; area under the curve (AUC), 0.85; P < 0.001]. The improvement in early- and late-systolic MR was also associated with LV reverse remodelling, in which improvement in early-systolic MR had higher sensitivity, specificity, and AUC than late-systolic MR. The extent of reverse remodelling with gain in LV ejection fraction and forward stroke volume was greatest in patients with improvement in total MR, intermediate in those with mild or no MR at baseline, and the least in those without improvement in total MR (LVESV, -29.8 +/- 12.0 vs. -18.6 +/- 16.6 vs. -5.5 +/- 8.6%; ejection fraction, 11.8 +/- 6.2 vs. 7.0 +/- 6.8 vs. 3.0 +/- 5.0%; forward stroke volume, 43.1 +/- 37.9 vs. 21.1 +/- 26.1 vs. 6.8 +/- 34.6%; all P < 0.05). Improvement of functional MR contributes to LV reverse remodelling after CRT, whereas reduction of early-systolic MR is more powerful than late-systolic MR.
收录类别	SCI
原文出处	http://eurheartj.oxfordjournals.org/content/ehj/31/19/2359.full.pdf
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/2970]
专题	深圳先进技术研究院_医工所
作者单位	EUROPEAN HEART JOURNAL
推荐引用方式 GB/T 7714	Yu-Jia Liang,Qing Zhang,Jeffrey Wing-Hong Fung,et al. Impact of reduction in early- and late-systolic functional mitral regurgitation on reverse remodeling after cardiac resynchronization therapy[J]. EUROPEAN HEART JOURNAL,2010,31(19):2359-2368.
APA	Yu-Jia Liang.,Qing Zhang.,Jeffrey Wing-Hong Fung.,Joseph Yat-Sun Chan.,Gabriel Wai-Kwok Yip.,...&Cheuk-Man Yu.(2010).Impact of reduction in early- and late-systolic functional mitral regurgitation on reverse remodeling after cardiac resynchronization therapy.EUROPEAN HEART JOURNAL,31(19),2359-2368.
MLA	Yu-Jia Liang,et al."Impact of reduction in early- and late-systolic functional mitral regurgitation on reverse remodeling after cardiac resynchronization therapy".EUROPEAN HEART JOURNAL 31.19(2010):2359-2368.