Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases

	Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases
	Tu Jie; Wang Li-Ping
刊名	NEUROSCIENCE BULLETIN
	2009
卷号	25 期号:1 页码:27-32
英文摘要	Extracellular adenosine 5'-triphosphate (ATP) is a key signaling molecule present in the central nervous system (CNS), and now is receiving greater attention due to its role as a messenger in the CNS during different physiological and pathological events. ATP is released into the extracellular space through vesicular exocytosis or from damaged and dying cells. Once in the extracellular environment, ATP binds to the specific receptors termed P2, which mediate ATP effects and are present broadly in both neurons and glial cells. There are P2X, the ligand-gated ionotropic receptors, possessing low affinity for ATP and responsible for fast excitatory neurotransmission, and P2Y, the metabotropic G-protein-coupled receptors, possessing high affinity for ATP. Since massive extracellular release of ATP often occurs after stress, brain ischemia and trauma, the extracellular ATP is considered relating to or involving in the pathological processes of many nervous system diseases. Conversely, the trophic functions have also been extensively described for the extracellular ATP. Therefore, extracellular ATP plays a very complex role in the CNS and its binding to P2 receptors can be related to toxic and/or beneficial effects. In this review, we described the extracellular ATP acting via P2 receptors as a potent therapeutic target for treatment of nervous system diseases.
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pubmed/19190686
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/2552]
专题	深圳先进技术研究院_医工所
作者单位	NEUROSCIENCE BULLETIN
推荐引用方式 GB/T 7714	Tu Jie,Wang Li-Ping. Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases[J]. NEUROSCIENCE BULLETIN,2009,25(1):27-32.
APA	Tu Jie,&Wang Li-Ping.(2009).Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases.NEUROSCIENCE BULLETIN,25(1),27-32.
MLA	Tu Jie,et al."Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases".NEUROSCIENCE BULLETIN 25.1(2009):27-32.