| In vivo study of a novel magnesium composed PLGATCP porous scaffold fabricated by 3D printing for bone regeneration | |
| Ye Li; Long Li; Huijuan Cao; Yuxiao Lai; Xinluan Wang; Ling Qin | |
| 2015 | |
| 会议名称 | 2015 International Children Medical Research Society（ICMRS 2015） |
| 会议地点 | 长沙 |
| 英文摘要 | Objective This study aimed to investigate the differentiation of the proliferation and osteogenic properties of bone marrow mesenchymal stem cells(BMSCs) between collagen induced arthritis rat model and normal rat. Methods BMSCs were Isolated, cultured and identified by flow cytometry Objective: Bone regeneration is a crucial event in bone tissue engineering, and there has been an increasing interest in the use of bone graft substitutes made of naturally derived and synthetic during the past decades due to their readily production, available application, and lack of immunogenicity. An innovative Mg associated bioactive porous scaffold composed of poly (lactide-co-glycolide, PLGA), b-tricalcium phosphate (TCP) and magnesium (Mg) with well-defined biomimic microstructure for bone regeneration was designed and fabricated by low-temperature 3D printing technology. In this study, we aim to investigate the in vivo osteogenetic ability and the mechanical properties of PLGA/TCP/Mg porous scaffold. Material and methods: Sixty-one-16-week-male rabbit of 2.5-3 kg were used to establish SAON models according to our published paper. Under general anesthesia, core decompression was conducted on the femoral condyle of the rabbit by drilling a 3.0 mm tunnel transversely through the distal femur. The distal femurs were randomly divided into three groups: (i) control group without any treatment, (ii) PLGA/TCP group with PLGA/TCP scaffold implanted into the bone tunnel, and (iii) PLGA/TCP/Magnesium group with PLGA/TCP/Magnesium implanted into the bone tunnel. After 2,4,8,12,16 weeks, the rabbits were sacrificed and both femurs were removed. Micro-CT scanning was used to analysis the in vivo osteogenetic effect of the PLGA/TCP/Magnesium Results: The 3D micro-CT images in Fig.1 and the 2D X-ray images in Fig.2 show that the defects with no implantation were filled with little bony structure. Bone defects |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 内容类型 | 会议论文 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7312]  |
| 专题 | 深圳先进技术研究院_医工所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Ye Li,Long Li,Huijuan Cao,et al. In vivo study of a novel magnesium composed PLGATCP porous scaffold fabricated by 3D printing for bone regeneration[C]. 见:2015 International Children Medical Research Society（ICMRS 2015）. 长沙. |
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