QQ客服 官方微博 反馈留言

	Indocyanine Green Loaded Reduced Graphene Oxide for Photoacoustic/Fluorescence Dual-Modality Tumor Imaging
	Jingqin Chen; Chengbo Liu; Liang Song
	2015
会议名称	The International Conference on Biomedical and Health Informatics（BHI）
会议地点	Haikou
英文摘要	Herein, we synthesized indocyanine green (ICG) loaded, PEGylated, reduced nano-graphene oxide (rNGO-PEG/ICG), which provide excellent fluorescence imaging capability and greatly enhanced optical absorption for photoacoustic imaging (Figure 1). In vitro confocal fluorescence microscopy study showed that the rNGO-PEG/ICG can be effectively uptaken by Hela cells. Moreover, it exhibited an excellent passive targeting capability for in vivo tumor imaging. Compared with free ICG, rNGO-PEG/ICG, upon intravenous injection, was able to provide greatly enhanced fluorescence and photoacoustic imaging contrasts of tumors in mice (Figure 2 and 3). In addition, the circulation time of rNGO-PEG/ICG in the mouse body sustained up to six hours post injection; while after one day, no obvious accumulation of rNGO-PEG/ICG was found in any major organs (liver, spleen, kidney etc.), except the tumor regions. The demonstrated high fluorescence/photoacoustic dual-contrasts, together with its low toxicity and excellent circulation life time, suggests that the synthesized rNGO-PEG/ICG can be a promising candidate for further translational studies on both the early diagnosis and image-guided therapy/surgery of cancer.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7217]
专题	深圳先进技术研究院_医工所
作者单位	2015
推荐引用方式 GB/T 7714	Jingqin Chen,Chengbo Liu,Liang Song. Indocyanine Green Loaded Reduced Graphene Oxide for Photoacoustic/Fluorescence Dual-Modality Tumor Imaging[C]. 见:The International Conference on Biomedical and Health Informatics（BHI）. Haikou.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。