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	Indocyanine green loaded, PEGylated, reduced graphene oxide as a highly efficient passive targeting contrast agent for photoacoustic/fluorescence dual-modality tumor imaging
	Jingqin Chen; Chengbo Liu; Liang Song
	2015
会议名称	International Conference on Nanomedicine and NanoBiotechnology
会议地点	Hangzhou
英文摘要	Multi-modality imaging based on multifunctional nanoparticles holds great promise to fundamentally augment the capability of biomedical imaging, for both the diagnosis and therapy of tumor. Herein, we developed a green and facile method to prepare PEGylated, reduced nano-graphene oxide (rNGO-PEG) from covalently PEGylated nano-graphene oxide (NGO-PEG). The rNGO-PEG was further loaded with indocyanine green (ICG) and was shown to simultaneously offer excellent fluorescence imaging capability and greatly enhanced optical absorption for photoacoustic imaging. In vitro laser confocal fluorescence microscopy study showed that the ICG loaded rNGO-PEG (rNGO-PEG/ICG) can be effectively uptaken by Hela cells into the cytoplasm area. Moreover, in vivo imaging experiments demonstrated that, compared with free ICG, upon intravenous injection, rNGO-PEG/ICG was able to provide greatly enhanced fluorescence and photoacoustic imaging contrasts of the tumor region. Finally, we found that the signals of rNGO-PEG/ICG in the tumor region and mouse body could sustain up to 6 hours post injection; while after one day, no obvious accumulation of rNGO-PEG/ICG was observed from all the major organs (liver, spleen, kidney etc.), except the tumors, excised from the experimented mice, suggesting that the rNGO-PEG/ICG had a life time highly suitable for biomedical imaging. Overall, the synthesized rNGO-PEG/ICG had an excellent passive targeting capability for in vivo tumor imaging, presumably due to the enhanced permeability and retention (EPR) effect. In addition, the demonstrated low toxicity, excellent life time, and high fluorescence/photoacoustic dual-contrasts of the synthesized rNGO-PEG/ICG make it a promising candidate for further biomedical imaging translational studies for the early detection, diagnosis, and image-guided therapy of tumor.
收录类别	其他
语种	英语
WOS记录号	WOS:000373923400213
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7216]
专题	深圳先进技术研究院_医工所
作者单位	2015
推荐引用方式 GB/T 7714	Jingqin Chen,Chengbo Liu,Liang Song. Indocyanine green loaded, PEGylated, reduced graphene oxide as a highly efficient passive targeting contrast agent for photoacoustic/fluorescence dual-modality tumor imaging[C]. 见:International Conference on Nanomedicine and NanoBiotechnology. Hangzhou.

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