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	The treatment effects of HET0016 on demyelinating mice induced by cuprizone
	Huina Wang; Lei Jin; Wei Yu; Li Chen; Xiaoming Ouyang; Xue Wang; Jing Yang
	2012
会议名称	Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics, BHI 2012,
会议地点	香港
英文摘要	Cytochrome P450s (CYP) ω-hydroxylase and its metabolites 20 - hydroxyeicosatetraenoic acid (20-HETE) play an important role in the central nervous system disorders. The purpose of this study was to determine the effects of the 20-HETE inhibitor, HET0016, on myelin sheath after demylination in mice. Methods: We have studied the impact of HET0016 on remyelination using the toxic cuprizone model. Animals were assigned randomly to various groups and injected intraperitoneally with 10% lecithin or 2.0 and 0.2 mg/kg of HET0016 per day in 2 weeks. The animals were killed and the brains were reserved. We investigated spatial memory of mice using the Y-maze. We observed the myelin of corpus callosum by histochemical staining. Results: there were no significant differences in body weight, food intake and water intake between the model group and HET0016 (2.0mg/kg, 0.2mg/kg) group; spatial memory improved significantly in HET0016 (0.2mg/kg, 2.0mg/kg) group compared with model group; corpus callosum structure was significantly remyelinated after 2 weeks by HET0016 treatment. Conclusion: HET0016, a selective inhibitor of CYP ω-hydroxylase, has potent therapeutic effect on multiple sclerosis mice.
收录类别	EI
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4133]
专题	深圳先进技术研究院_医工所
作者单位	2012
推荐引用方式 GB/T 7714	Huina Wang,Lei Jin,Wei Yu,et al. The treatment effects of HET0016 on demyelinating mice induced by cuprizone[C]. 见:Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics, BHI 2012,. 香港.

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