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	LyP-1 Ultrasonic Microbubbles Targeting to Cancer Cell as Tumor Bioacoustics Markers or Drug Carriers: Targeting Efficiency Evaluation in Microfluidic Channels
	Xiang Li; Qiaofeng Jin; Tan Chen; Baoyue Zhang; Rongqin Zheng; Zhanhui Wang; Hairong Zheng
	2009
会议名称	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
英文摘要	Using ultrasonic contrast microbubbles as acoustic biomarkers and drug carrier vehicles by conjugating tumor specific antibody to microbubbles has shown great potential in ultrasonic tumor molecular imaging or drug-delivery and therapy. Microbubble probe targeting efficiency is one of the major challenges. In this study, we developed a novel method to evaluate the targeting capability and efficiency of microbubbles to cells, and more specifically, microbubbles binding LyP-1 (a cyclic nonapeptide acid peptide) target to cancer cell within a microfluidic system. The micro cell sieves within the microfludic channels could trap the tumor cells and enhance the microbubble's interaction with the cell. Assisted with the controllable fluid shear stress, the microbubble's targeting to the cell and the corresponding affinity efficiency could be quantitatively evaluated under a florescent microscope. The system provides a useful low-cost high efficient in vitro platform for studying microbubble-cell interaction for ultrasonic tumor molecular imaging or drugdelivery and therapy.
收录类别	EI
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/2581]
专题	深圳先进技术研究院_医工所
作者单位	2009
推荐引用方式 GB/T 7714	Xiang Li,Qiaofeng Jin,Tan Chen,et al. LyP-1 Ultrasonic Microbubbles Targeting to Cancer Cell as Tumor Bioacoustics Markers or Drug Carriers: Targeting Efficiency Evaluation in Microfluidic Channels[C]. 见:31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009.

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