Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: diffuse and sustained

	Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: diffuse and sustained
	Zhen-Ni Guo; Yingqi Xing; Shuang Wang; Hongyin Ma; Jia Liu; Yi Yan
刊名	Scientific Reports
	2015
英文摘要	Cerebral small vessel disease is a major cause of stroke and vascular dementia; however, the pathogenesis is largely unclear. In this study, we investigated the characteristics of the impairment of dynamic cerebral autoregulation (dCA) in lacunar infarction patients. Seventy-one lacunar infarction patients were enrolled in the study, including 46 unilateral middle cerebral artery (MCA) territory stroke patients and 25 unilateral posterior cerebral artery (PCA) territory stroke patients. Each group of patients was randomly divided into two subgroups. Group 1 underwent dCA assessments in the bilateral MCAs, and Group 2 underwent dCA assessments in the bilateral PCAs. All patients were followed up for 6 months. Transfer function analysis was applied to derive the autoregulatory parameters of gain and phase difference. In the unilateral MCA territory stroke patients, impairments of dCA were observed in both the MCAs and PCAs, and the same results were observed in the unilateral PCA territory stroke patients. These impairments remained unchanged during the 6-month follow-up. In lacunar infarction, which is most prevalent type of cerebral small vessel disease, though patients with unilateral MCA territory/PCA territory stroke, the impairments of dCA were global and sustained. This finding suggests that the physiological changes associated with lacunar infarction were diffuse.
收录类别	SCI
原文出处	http://www.nature.com/articles/srep15269
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6912]
专题	深圳先进技术研究院_数字所
作者单位	Scientific Reports
推荐引用方式 GB/T 7714	Zhen-Ni Guo,Yingqi Xing,Shuang Wang,et al. Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: diffuse and sustained[J]. Scientific Reports,2015.
APA	Zhen-Ni Guo,Yingqi Xing,Shuang Wang,Hongyin Ma,Jia Liu,&Yi Yan.(2015).Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: diffuse and sustained.Scientific Reports.
MLA	Zhen-Ni Guo,et al."Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: diffuse and sustained".Scientific Reports (2015).