Thermodynamics-Based Models of Transcriptional Regulation with Gene Sequence | |
Wang Shuqiang; Shen Yanyan; Hu Jinxing | |
刊名 | Bioprocess and Biosystems Engineering
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2015 | |
英文摘要 | Quantitative models of gene regulatory activity have the potential to improve our mechanistic understanding of transcriptional regulation. However, the few models available today have been based on simplistic assumptions about the sequences being modeled or heuristic approximations of the underlying regulatory mechanisms. In this work, we have developed a thermodynamics-based model to predict gene expression driven by any DNA sequence. The proposed model relies on a continuous time, differential equation description of transcriptional dynamics. The sequence features of the promoter are exploited to derive the binding affinity which is derived based on statistical molecular thermodynamics. Experimental results show that the proposed model can effectively identify the activity levels of transcription factors and the regulatory parameters. Comparing with the previous models, the proposed model can reveal more biological sense. |
收录类别 | SCI |
原文出处 | http://link.springer.com/article/10.1007%2Fs00449-015-1484-6 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.siat.ac.cn:8080/handle/172644/6861] ![]() |
专题 | 深圳先进技术研究院_数字所 |
作者单位 | Bioprocess and Biosystems Engineering |
推荐引用方式 GB/T 7714 | Wang Shuqiang,Shen Yanyan,Hu Jinxing. Thermodynamics-Based Models of Transcriptional Regulation with Gene Sequence[J]. Bioprocess and Biosystems Engineering,2015. |
APA | Wang Shuqiang,Shen Yanyan,&Hu Jinxing.(2015).Thermodynamics-Based Models of Transcriptional Regulation with Gene Sequence.Bioprocess and Biosystems Engineering. |
MLA | Wang Shuqiang,et al."Thermodynamics-Based Models of Transcriptional Regulation with Gene Sequence".Bioprocess and Biosystems Engineering (2015). |
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