Poly(styrenesulfonate)-Modified Ni-Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform | |
Ge, Naijian1; Wang, Donghui2; Peng, Feng2; Li, Jinhua2; Qiao, Yuqin2; Liu, Xuanyong2 | |
刊名 | ACS APPLIED MATERIALS & INTERFACES
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2016-09-21 | |
卷号 | 8期号:37页码:24491-24501 |
关键词 | Ni-Ti LDH cancer pH-responsive PSS drug internalization drug-eluting stents |
英文摘要 | Drug-eluting stents (DESs) are widely used in the palliative treatment of many kinds of cancers. However, the covered polymers used in DESs are usually associated with stent migration and acute cholecystins. Therefore, developing noncovered drug loading layers on metal stents is of great importance. In this. work, Ni-Ti layered double llyaroxide (Ni-Ti-LDH) films were prepared on the surface of nitinol Via hydrothermal treatment, and the LDH films were further modified by poly(styrenesulfonate) (PSS). The anticancer drug doxorubicin could be effectively loaded Onto the modified films, and drug release could be smartly controlled by the pH. Besides, the drug,absorption amounts of cancer cells cultured On the films could be effectively improved, These results indicate that the PSS-modified-LDH film may become a promising-drug loading platform that can be used in-the design of DESs. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
关键词[WOS] | IN-VITRO ; COATING STENTS ; PH DYNAMICS ; TITANIUM ; DELIVERY ; RELEASE ; NANOPARTICLES ; ADHESION ; POLYMER ; CANCER |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000384033600026 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/22140] ![]() |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Second Mil Med Univ, Eastern Hepatobilialy Surg Hosp, Intervent Ctr, Shanghai 200438, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
推荐引用方式 GB/T 7714 | Ge, Naijian,Wang, Donghui,Peng, Feng,et al. Poly(styrenesulfonate)-Modified Ni-Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(37):24491-24501. |
APA | Ge, Naijian,Wang, Donghui,Peng, Feng,Li, Jinhua,Qiao, Yuqin,&Liu, Xuanyong.(2016).Poly(styrenesulfonate)-Modified Ni-Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform.ACS APPLIED MATERIALS & INTERFACES,8(37),24491-24501. |
MLA | Ge, Naijian,et al."Poly(styrenesulfonate)-Modified Ni-Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform".ACS APPLIED MATERIALS & INTERFACES 8.37(2016):24491-24501. |
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