Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing
	Yu, Weilin 1; Jiang, Ying-Ying 2; Sun, Tuan-Wei 2; Qi, Chao 2; Zhao, Huakun 1; Chen, Feng 2; Shi, Zhongmin 1; Zhu, Ying-Jie 2; Chen, Daoyun 1; He, Yaohua 1
刊名	RSC ADVANCES
	2016
卷号	6 期号:106 页码:104375-104387
英文摘要	Wound dressings with pro-angiogenic activity are desirable for the rapid healing of full-thickness cutaneous wounds. It is well accepted that simvastatin can stimulate angiogenesis in addition to its lipid-lowering efficacy. However, the construction of a hydrogel-based wound dressing containing simvastatin remains a challenge due to its water-insolubility. In the present study, a novel wound dressing composed of alginate hydrogel (AH) and simvastatin-incorporated mesoporous hydroxyapatite microspheres (S-MHMs) was constructed for the sustained drug release of simvastatin. We first investigated the effect of simvastatin on the angiogenic differentiation of human umbilical vein endothelial cells (HUVECs). The in vitro results revealed that simvastatin significantly promoted the migration and tube formation of HUVECs. Furthermore, the activation of the Akt and Erk signaling pathways was detected in HUVECs upon treatment with simvastatin, and enhanced tube formation was reversed by LY294002 and PD98059, which indicated that both the Akt and Erk signaling pathways were involved in the process of angiogenesis induced by simvastatin. Moreover, simvastatin significantly up-regulated the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF), which play essential roles in angiogenesis. For the in vivo experiments, simvastatin was incorporated into mesoporous hydroxyapatite microspheres (MHMs) synthesized using fructose 1,6-bisphosphate trisodium salt (FBP) as the phosphorous source by the microwave-assisted hydrothermal method. An simvastatin-loaded MHMs (S-MHMs) incorporated alginate hydrogel (S-MHMs/AH) was prepared as a wound dressing to promote the full-thickness cutaneous wound healing. The results demonstrated that S-MHMs/AH significantly enhanced new blood vessel formation and accelerated the reepithelialization of the cutaneous wounds. The present study suggests the potential application of the S-MHMs/AH composite as a novel dressing for wound healing.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	ENDOTHELIAL-CELLS ; DRUG-DELIVERY ; PROMOTES ANGIOGENESIS ; SIGNALING PATHWAYS ; PHOSPHORUS SOURCE ; ANTICANCER DRUG ; RELEASE ; ACTIVATION ; VEGF ; NANOPARTICLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000388111900061
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/21976]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Dept Orthoped, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, 1295 Dingxi Rd, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Yu, Weilin,Jiang, Ying-Ying,Sun, Tuan-Wei,et al. Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing[J]. RSC ADVANCES,2016,6(106):104375-104387.
APA	Yu, Weilin.,Jiang, Ying-Ying.,Sun, Tuan-Wei.,Qi, Chao.,Zhao, Huakun.,...&He, Yaohua.(2016).Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing.RSC ADVANCES,6(106),104375-104387.
MLA	Yu, Weilin,et al."Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing".RSC ADVANCES 6.106(2016):104375-104387.