Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery | |
Sun, Tuan-Wei1; Zhu, Ying-Jie1; Chen, Feng1; Qi, Chao1; Lu, Bing-Qiang1; Wu, Jin1; Zhou, Ding2; Zhang, Chang-Qing2 | |
刊名 | RSC ADVANCES
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2016 | |
卷号 | 6期号:105页码:103399-103411 |
英文摘要 | Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate (SPIO@MS) have been synthesized by a facile solvothermal approach based on a chemical-template etching mechanism using a mixed solution containing magnesium ions and acetate ions. The effects of the solvothermal time and the amount of MgCl2.6H(2)O as the magnesium source on the morphology of yolk-shell porous nanospheres of SPIO@MS are investigated, and the possible formation mechanism of yolk-shell porous nanospheres of SPIO@MS is proposed. The yolk-shell porous nanospheres of SPIO@MS prepared using 0.9 mmol MgCl2.6H(2)O at 180 degrees C for 24 h exhibit a high specific surface area (392.4 m(2) g(-1)) and doxorubicin hydrochloride (DOX) loading amount (526 mg g(-1)). More importantly, the SPIO@MS/DOX drug delivery system exhibits a sustained and pH-responsive drug release performance, and a much higher anticancer activity than free DOX in vitro. Therefore, the as-prepared yolk-shell porous nanospheres of SPIO@MS are promising for application in high-performance drug delivery. |
WOS标题词 | Science & Technology ; Physical Sciences |
类目[WOS] | Chemistry, Multidisciplinary |
研究领域[WOS] | Chemistry |
关键词[WOS] | MAGNETIC CORE-SHELL ; ADENOSINE 5'-TRIPHOSPHATE ; AQUEOUS-SOLUTION ; HOLLOW SPHERES ; CANCER-THERAPY ; NANOPARTICLES ; MICROSPHERES ; WATER ; ADSORPTION ; PHOSPHATE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000387726500070 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/21964] ![]() |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped Surg, Shanghai 200233, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Tuan-Wei,Zhu, Ying-Jie,Chen, Feng,et al. Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery[J]. RSC ADVANCES,2016,6(105):103399-103411. |
APA | Sun, Tuan-Wei.,Zhu, Ying-Jie.,Chen, Feng.,Qi, Chao.,Lu, Bing-Qiang.,...&Zhang, Chang-Qing.(2016).Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery.RSC ADVANCES,6(105),103399-103411. |
MLA | Sun, Tuan-Wei,et al."Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery".RSC ADVANCES 6.105(2016):103399-103411. |
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