Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery
	Sun, Tuan-Wei 1; Zhu, Ying-Jie 1; Chen, Feng 1; Qi, Chao 1; Lu, Bing-Qiang 1; Wu, Jin 1; Zhou, Ding 2; Zhang, Chang-Qing 2
刊名	RSC ADVANCES
	2016
卷号	6 期号:105 页码:103399-103411
英文摘要	Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate (SPIO@MS) have been synthesized by a facile solvothermal approach based on a chemical-template etching mechanism using a mixed solution containing magnesium ions and acetate ions. The effects of the solvothermal time and the amount of MgCl2.6H(2)O as the magnesium source on the morphology of yolk-shell porous nanospheres of SPIO@MS are investigated, and the possible formation mechanism of yolk-shell porous nanospheres of SPIO@MS is proposed. The yolk-shell porous nanospheres of SPIO@MS prepared using 0.9 mmol MgCl2.6H(2)O at 180 degrees C for 24 h exhibit a high specific surface area (392.4 m(2) g(-1)) and doxorubicin hydrochloride (DOX) loading amount (526 mg g(-1)). More importantly, the SPIO@MS/DOX drug delivery system exhibits a sustained and pH-responsive drug release performance, and a much higher anticancer activity than free DOX in vitro. Therefore, the as-prepared yolk-shell porous nanospheres of SPIO@MS are promising for application in high-performance drug delivery.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	MAGNETIC CORE-SHELL ; ADENOSINE 5'-TRIPHOSPHATE ; AQUEOUS-SOLUTION ; HOLLOW SPHERES ; CANCER-THERAPY ; NANOPARTICLES ; MICROSPHERES ; WATER ; ADSORPTION ; PHOSPHATE
收录类别	SCI
语种	英语
WOS记录号	WOS:000387726500070
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/21964]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped Surg, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Sun, Tuan-Wei,Zhu, Ying-Jie,Chen, Feng,et al. Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery[J]. RSC ADVANCES,2016,6(105):103399-103411.
APA	Sun, Tuan-Wei.,Zhu, Ying-Jie.,Chen, Feng.,Qi, Chao.,Lu, Bing-Qiang.,...&Zhang, Chang-Qing.(2016).Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery.RSC ADVANCES,6(105),103399-103411.
MLA	Sun, Tuan-Wei,et al."Superparamagnetic yolk-shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery".RSC ADVANCES 6.105(2016):103399-103411.