3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration | |
Ma, Hongshi1; Luo, Jian2,3; Sun, Zhe2,3; Xia, Lunguo4; Shi, Mengchao1; Liu, Mingyao2,3; Chang, Jiang1; Wu, Chengtie1 | |
刊名 | BIOMATERIALS |
2016-12-01 | |
卷号 | 111页码:138-148 |
关键词 | 3D-printed scaffolds Mussel-inspired nanostructure Bioactivity Tumor therapy Tissue engineering |
英文摘要 | Primary bone cancer brings patients great sufferings. To deal with the bone defects resulted from cancer surgery, biomaterials with good bone-forming ability are necessary to repair bone defects. Meanwhile, in order to prevent possible tumor recurrence, it is essential that the remaining tumor cells around, bone defects are completely killed. However, there are few biomaterials with the ability of both cancer therapy and bone regeneration until now. Here, we fabricated a 3D-printed bioceramic scaffold with a uniformly self-assembled Ca-P/polydopamine nanolayer surface. Taking advantage of biocompatibility, biodegradability and the excellent photothermal effect of polydopamine, the bifunctional scaffolds with mussel-inspired nanostructures could be used as a satisfactory and controllable photothermal agent, which effectively induced tumor cell death in vitro, and significantly inhibited tumor growth in mice. In addition, owing to the nanostructured surface, the prepared polydopamine-modified bioceramic scaffolds could support the attachment and proliferation of rabbit bone mesenchymal stem cells (rBMSCs), and significantly promoted the formation of new bone tissues in rabbit bone defects even under photothermal treatment. Therefore, the mussel-inspired nanostructures in 3D-printed bioceramic exhibited a remarkable capability for both cancer therapy and bone regeneration, offering a promising strategy to construct bifunctional biomaterials which could be widely used for therapy of tumor-induced tissue defects. (C) 2016 Elsevier Ltd. All rights reserved. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
研究领域[WOS] | Engineering ; Materials Science |
关键词[WOS] | GUIDED PHOTOTHERMAL THERAPY ; MARROW STROMAL CELLS ; BIOMEDICAL APPLICATIONS ; CANCER-THERAPY ; IN-VIVO ; DIFFERENTIATION ; POLYDOPAMINE ; BIOCERAMICS ; CHEMISTRY ; NANOPARTICLES |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000388047900012 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/21958] |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Shanghai Inst Ceram, Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 3.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 4.Shanghai Jiao Tong Univ, Peoples Hosp 9, Ctr Craniofacial Orthodont, Dept Oral & Craniomaxillofacial, Shanghai 20001, Peoples R China |
推荐引用方式 GB/T 7714 | Ma, Hongshi,Luo, Jian,Sun, Zhe,et al. 3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration[J]. BIOMATERIALS,2016,111:138-148. |
APA | Ma, Hongshi.,Luo, Jian.,Sun, Zhe.,Xia, Lunguo.,Shi, Mengchao.,...&Wu, Chengtie.(2016).3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration.BIOMATERIALS,111,138-148. |
MLA | Ma, Hongshi,et al."3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration".BIOMATERIALS 111(2016):138-148. |
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