Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T-1-weighted magnetic resonance imaging

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T-1-weighted magnetic resonance imaging
	Li, X. W.1; Zhao, W. R.1; Liu, Y. J.2; Liu, X. H.3; Shi, P.2; Li, Y. S.1; Shi, J. L.1,4
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2016
卷号	4 期号:24 页码:4313-4321
英文摘要	Contrast agents (CAs) play an important role in enhancing the magnetic resonance imaging (MRI) performance for accurate tumor diagnosis, which, however, may give rise to unexceptional issues such as in vivo accumulation and bio-toxicity. Here we report on manganese silicate nanoparticles (denoted as MnSNs) as highly biocompatible and pH/GSH-responsive T-1-weighted MRI CAs. The MnSNs were synthesized via a facile, cost-effective and environmentally friendly route based on one-step rapid precipitation between the Mn2+ cation and the SiO32- anion in aqueous solution at room temperature without any other additives, and showed excellent dispersion stability in water or PBS for weeks without any surface modification at ambient temperature. The MnSNs present an efficient pH/GSH-responsive T-1-MRI feature based on the rapid changes in the relaxation rate in a mildly acidic/reducing environment both in vitro and in vivo, and furthermore, MnSNs showed negligible cellular cytotoxicity in vitro, no distinct tissue toxicity in vivo and fast clearance from the body organs and tissues in 24-72 h. Thus, the MnSNs are able to serve as a novel class of highly promising T-1-MRI CAs for clinical cancer diagnosis.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Materials Science, Biomaterials
研究领域[WOS]	Materials Science
关键词[WOS]	MRI CONTRAST AGENTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; GLUTATHIONE LEVELS ; MESOPOROUS SILICA ; CANCER-CELLS ; INORGANIC NANOPARTICLES ; OXIDE NANOPARTICLES ; DRUG-DELIVERY ; GADOLINIUM ; TISSUE
收录类别	SCI
语种	英语
WOS记录号	WOS:000378936400009
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/22081]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China 3.Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Li, X. W.,Zhao, W. R.,Liu, Y. J.,et al. Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T-1-weighted magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(24):4313-4321.
APA	Li, X. W..,Zhao, W. R..,Liu, Y. J..,Liu, X. H..,Shi, P..,...&Shi, J. L..(2016).Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T-1-weighted magnetic resonance imaging.JOURNAL OF MATERIALS CHEMISTRY B,4(24),4313-4321.
MLA	Li, X. W.,et al."Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T-1-weighted magnetic resonance imaging".JOURNAL OF MATERIALS CHEMISTRY B 4.24(2016):4313-4321.