High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues | |
Yang WG(杨文广); Yu HB(于海波); Wang YC(王越超); Liu LQ(刘连庆) | |
刊名 | Small |
2017 | |
卷号 | 13期号:5页码:1-11 |
ISSN号 | 1613-6810 |
通讯作者 | 于海波 ; 刘连庆 |
产权排序 | 1 |
中文摘要 | 3D hydrogel microstructures that encapsulate cells have been used in broad applications in microscale tissue engineering, personalized drug screening, and regenerative medicine. Recent technological advances in microstructure assembly, such as bioprinting, magnetic assembly, microfluidics, and acoustics, have enabled the construction of designed 3D tissue structures with spatially organized cells in vitro. However, a bottleneck exists that still hampers the application of microtissue structures, due to a lack of techniques that combined high-throughput fabrication and flexible assembly. Here, a versatile method for fabricating customized microstructures and reorganizing building blocks composed of functional components into a combined single geometric shape is demonstrated. The arbitrary microstructures are dynamically synthesized in a microfluidic device and then transferred to an optically induced electrokinetics chip for manipulation and assembly. Moreover, building blocks containing different cells can be arranged into a desired geometry with specific shape and size, which can be used for microscale tissue engineering. |
WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
关键词[WOS] | STOP-FLOW LITHOGRAPHY ; DIELECTROPHORETIC ODEP FORCE ; OPTOELECTRONIC TWEEZERS ; 2-PHOTON POLYMERIZATION ; MICROFLUIDIC PLATFORM ; PRINTING TECHNOLOGY ; DRUG-DELIVERY ; STEM-CELLS ; HYDROGELS ; MICROPARTICLES |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000397009300010 |
内容类型 | 期刊论文 |
源URL | [http://ir.sia.cn/handle/173321/19887] |
专题 | 沈阳自动化研究所_机器人学研究室 |
推荐引用方式 GB/T 7714 | Yang WG,Yu HB,Wang YC,et al. High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues[J]. Small,2017,13(5):1-11. |
APA | Yang WG,Yu HB,Wang YC,&Liu LQ.(2017).High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues.Small,13(5),1-11. |
MLA | Yang WG,et al."High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues".Small 13.5(2017):1-11. |
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