Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 转化基因组

	Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
	Wu LC[]1; Wang GZ 2; Yang FF 1,2; Li M 5; Zhou GB 2; Wang LS[]1; Wei JR 3; Huang N 4; Zhang S 1
刊名	Oncotarget
	2016
卷号	X 期号:X 页码:XX-XX
关键词	Skp2 lung cancer matrine derivative migration proliferation
通讯作者	wulichuan@126.com ; w_lsheng@163.com
英文摘要	Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dose-dependent manner. The findings indicate that YF-18 bears therapeutic potentials for lung cancer.
收录类别	SCI
资助信息	The present study was financially supported by the National Natural Science Foundation of China (No. 21262005), the high level innovation team and outstanding scholar project of Guangxi institutions of higher education (gui jiao ren [2014] 49 hao), the Postdoctoral Science Foundation of Guangxi Province of China (Y201001928), the Scientific Research Foundation of Guangxi University (No. XJZ160924) the National Natural Science Funds for Distinguished Young Scholar (81425025), and the class General Financial Grant from the China Postdoctoral Science Foundation (2015M581172). We thank Professor Hu Tingjun of School of Zoology Science and Technology of Guangxi University for the experimental support.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10793]
专题	昆明动物研究所_转化基因组昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, PR China 2.State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China 3.Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi, PR China 4.Affiliated Tumour Hospital of Guangxi Medical University, Nanning, Guangxi, PR China 5.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Wu LC[*],Wang GZ,Yang FF,et al. Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2[J]. Oncotarget,2016,X(X):XX-XX.
APA	Wu LC[*].,Wang GZ.,Yang FF.,Li M.,Zhou GB.,...&Zhang S.(2016).Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.Oncotarget,X(X),XX-XX.
MLA	Wu LC[*],et al."Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2".Oncotarget X.X(2016):XX-XX.