Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew.

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew.
	Xu L 1; Yu DD 1; Yao YG[*]1,2,3; Fan Y 1; Peng L 1; Wu Y 1,2
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2016
卷号	113 期号:39 页码:10950-10955
关键词	RIG-I RIG-I functional replacement positive selection tree shrew
通讯作者	yaoyg@mail.kiz.ac.cn
合作状况	其它
英文摘要	The function of the RIG-I-like receptors (RLRs; including RIG-I, MDA5, and LGP2) as key cytoplasmic sensors of viral pathogen-associated molecular patterns (PAMPs) has been subjected to numerous pathogenic challenges and has undergone a dynamic evolution. We found evolutionary evidence that RIG-I was lost in the Chinese tree shrew lineage. Along with the loss of RIG-I, both MDA5 (tMDA5) and LGP2 (tLGP2) have undergone strong positive selection in the tree shrew. tMDA5 or tMDA5/tLGP2 could sense Sendai virus (an RNA virus posed as a RIG-I agonist) for inducing type I IFN, although conventional RIG-I and MDA5 were thought to recognize distinct RNA structures and viruses. tMDA5 interacted with adaptor tMITA (STINGTMEM173/ERIS), which was reported to bind only with RIG-I. The positively selected sites in tMDA5 endowed the substitute function for the lost RIG-I. These findings provided insights into the adaptation and functional diversity of innate antiviral activity in vertebrates.
收录类别	SCI
资助信息	This study was supported by National Natural Science Foundation of China Grant U14022
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10465]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Xu L,Yu DD,Yao YG[*],et al. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew.[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(39):10950-10955.
APA	Xu L,Yu DD,Yao YG[*],Fan Y,Peng L,&Wu Y.(2016).Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew..PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(39),10950-10955.
MLA	Xu L,et al."Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew.".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.39(2016):10950-10955.