Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile
	Zhang DF[]1,3; Wang D 1; Li YY 2; Yao YG[]1,3
刊名	JOURNAL OF DERMATOLOGICAL SCIENCE
	2016
卷号	82 期号:1 页码:18-27
关键词	Leprosy Susceptibility gene Enrichment Autoimmune Network
通讯作者	zhangdengfeng@mail.kiz.ac.cn
英文摘要	Background: Leprosy is an ancient chronic infection in the skin and peripheral nerves caused by Mycobacterium leprae. The development of leprosy depends on genetic background and the immune status of the host. However, there is no systematic view focusing on the biological pathways, interaction networks and overall expression pattern of leprosy-related immune and genetic factors. Objectives: To identify the hub genes in the center of leprosy genetic network and to provide an insight into immune and genetic factors contributing to leprosy. Methods: We retrieved all reported leprosy-related genes and performed integrative analyses covering gene expression profiling, pathway analysis, protein-protein interaction network, and evolutionary analyses. Results: A list of 123 differentially expressed leprosy related genes, which were enriched in activation and regulation of immune response, was obtained in our analyses. Cross-disorder analysis showed that the list of leprosy susceptibility genes was largely shared by typical autoimmune diseases such as lupus erythematosus and arthritis, suggesting that similar pathways might be affected in leprosy and autoimmune diseases. Protein-protein interaction (PPI) and positive selection analyses revealed a co-evolution network of leprosy risk genes. Conclusions: Our analyses showed that leprosy associated genes constituted a co-evolution network and might undergo positive selection driven by M. leprae. We suggested that leprosy may be a kind of autoimmune disease and the development of leprosy is a matter of defect or over-activation of body immunity.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foundation of China (31271346).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10310]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China
推荐引用方式 GB/T 7714	Zhang DF[*],Wang D,Li YY,et al. Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2016,82(1):18-27.
APA	Zhang DF[],Wang D,Li YY,&Yao YG[].(2016).Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile.JOURNAL OF DERMATOLOGICAL SCIENCE,82(1),18-27.
MLA	Zhang DF[*],et al."Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile".JOURNAL OF DERMATOLOGICAL SCIENCE 82.1(2016):18-27.