Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands
	Zhuang XY; Yao YG[*]
刊名	FEBS LETTERS
	2013
卷号	587 期号:11 页码:1656-1662
关键词	Telomerase G-quadruplex ligand Mitochondrial function Cell apoptosis
通讯作者	ygyaozh@gmail.com
合作状况	其它
英文摘要	G-quadruplex ligands DODC and TMPyP4 have different binding modes to quadruplex structure and cause cell proliferation arrest. Here we showed that DODC was more efficient in cell growth inhibition than TMPyP4. Both G-quadruplex ligands induced nuclear-cytoplasmic shuttling and accumulation of TERT in mitochondria. This effect was not fully dependent on cellular oxidative stress. DODC induced robust cell apoptosis by perturbing mitochondrial function intensively. Overexpression of TERT could not counteract the effects of DODC on mitochondrial respiratory function. Taken together, our results suggest that interference of mitochondrial function by DODC is one of main targets for its anti-tumor ability. (c) 2013 Federation of European Biochemical Societies
收录类别	SCI
资助信息	This work was supported by the Ministry of Science and Tech- nology of China (2011CB910900), ‘‘Light in Western China (西部之光)’’ of the Chinese Academy of Sciences and Yunnan Province (2009CI119).
语种	英语
WOS记录号	WOS:000319445900012
公开日期	2013-07-01
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7531]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Zhuang XY,Yao YG[*]. Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands[J]. FEBS LETTERS,2013,587(11):1656-1662.
APA	Zhuang XY,&Yao YG[*].(2013).Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands.FEBS LETTERS,587(11),1656-1662.
MLA	Zhuang XY,et al."Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands".FEBS LETTERS 587.11(2013):1656-1662.