Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 重大疾病机理的遗传学

	Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese
	Zhang W 1,3; Chen XG[]2; Gong W 1,4; Tang JS 2; Tan LW 2; Guo H 1,5; Yao YG[]1
刊名	BEHAVIORAL AND BRAIN FUNCTIONS
	2010
卷号	6 期号:X 页码:e75
通讯作者	chenxghn@gmail.com ; yaoyg@mail.kiz.ac.cn
合作状况	其它
英文摘要	Background: The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations. Methods: We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese. Results: Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese. Conclusion: The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301).
语种	英语
公开日期	2011-03-14
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6574]
专题	昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.The Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 4.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China 5.Department of Cardiology, Calmette Hospital, Kunming Medical College, Kunming, Yunnan 650011, China
推荐引用方式 GB/T 7714	Zhang W,Chen XG[*],Gong W,et al. Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2010,6(X):e75.
APA	Zhang W.,Chen XG[].,Gong W.,Tang JS.,Tan LW.,...&Yao YG[].(2010).Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.BEHAVIORAL AND BRAIN FUNCTIONS,6(X),e75.
MLA	Zhang W,et al."Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese".BEHAVIORAL AND BRAIN FUNCTIONS 6.X(2010):e75.