Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 肿瘤信号转导

	Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation
	Yan YM 1,4; Wang XL 1,3; Hou B 1; Zuo ZL 1; Chen YB[]5; Cheng YX[]1,2; Luo Q 1,4; Jiang LP 4,5; Yang CP 5
刊名	PHYTOCHEMISTRY
	2015
卷号	114 期号:SI 页码:155-162
关键词	Ganoderma lingzhi Ganodermataceae Meroterpenoids Neural stem cells Neurodegenerative diseases
通讯作者	ybchen@mail.kiz.ac.cn ; yxcheng@mail.kib.ac.cn
合作状况	其它
英文摘要	Ganoderma lingzhi is a valuable, edible and medicinal fungus that has been widely used for the prevention and treatment of a broad range of diseases. In this study, spirolingzhines A-D, four meroterpenoids with a spiro[benzofuran-2,1'-cyclopentanel motif, lingzhines A-F, six meroterpenoids with diverse ring systems, along with two known compounds were isolated from the fruiting bodies of this fungus. The structures and stereochemistry of these substances were determined by using spectroscopic, X-ray crystallographic and computational methods. Chiral HPLC was used to separate (-)- and (+)-antipodes of seven of ten meroterpenoids, which were isolated from the fungus as racemic mixtures. Several of the metabolites were found to promote proliferation of neural stem cells (NSCs) and, as such, they constitute a class of NSC stimulators. The most potent member of this series, (-)-spirolingzhine A, was shown to affect NSC cell cycle progression using the 5-bromo-2-deoxyuridine (BrdU) incorporation assay.
收录类别	SCI
资助信息	This work was supported by the Grants from NSFC-Joint Foundation of Yunnan Province (U1202222), the Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, National Natural Science Foundation of China (21472199, 81322030, 31271579), ‘‘South Drug’’ Research Collaborative Innovation Organization, Young and Middle Aged Academic Leaders of Kunming, West Light Foundation of the Chinese Academy of Sciences, National Key Basic Research Program of China (2013CB910900).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9327]
专题	昆明动物研究所_肿瘤信号转导昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China 2.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, People’s Republic of China 3.College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People’s Republic of China 4.University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 5.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, People’s Republic of China
推荐引用方式 GB/T 7714	Yan YM,Wang XL,Hou B,et al. Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation[J]. PHYTOCHEMISTRY,2015,114(SI):155-162.
APA	Yan YM.,Wang XL.,Hou B.,Zuo ZL.,Chen YB[*].,...&Yang CP.(2015).Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation.PHYTOCHEMISTRY,114(SI),155-162.
MLA	Yan YM,et al."Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation".PHYTOCHEMISTRY 114.SI(2015):155-162.