Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 肿瘤信号转导

	Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation
	Tang JJ 1,2; Zhang L 3; Jiang LP 5,6; Di L 1; Yan YM 1,6; Tu ZC[*]4; Yang CP 5,6; Zuo ZL 1; Hou B 1; Xia HL 2
刊名	TETRAHEDRON
	2014
卷号	70 期号:46 页码:8852-8857
关键词	Polyrhachis dives Dopamine derivative ROCK1/2 inhibitors NSCs
通讯作者	tu_zhengchao@gibh.ac.cn ; ybchen@mail.kiz.ac.cn ; yxcheng@mail.kib.ac.cn
合作状况	其它
英文摘要	Polyrhachis dives is consumed as an insect food in some regions of China. In this study, new dopamine derivatives, (+)-polyrhadopamine A (1a) and (-)-polyrhadopamine A (1b), (+)-polyrhadopamine B (2a) and (-)-polyrhadopamine B (2b), and polyrhadopamines C-E (3-5), were isolated from this species. The structures and stereochemistry of these substances were assigned by using spectroscopic and computational methods. Compounds 1a, 1b, 2a, and 2b are dimeric N-acetyldopamine derivatives, 3 is a dopamine analog containing an unusual sulfone group, and 4 and 5 possess a rare benzo[d]thiazole moiety. The functions of these substances as ROCK1/2 inhibitors, neural stem cell (NSCs) proliferation stimulators, immunosuppressive, and anti-inflammatory agents were determined.
收录类别	SCI
资助信息	This work was financially supported by National Natural Science Foundation of China (21272241; 21172223, 31271579, 81322030), the Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Middle Aged Academic Leaders of Kunming, a project from Center of Cooperative Innovation for South China Medicine of Yunnan Province, and National Key Basic Research Program of China (2013CB910900).
语种	英语
WOS记录号	WOS:000344204700007
公开日期	2014-12-05
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8188]
专题	昆明动物研究所_肿瘤信号转导昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 2.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, People’s Republic of China 3.Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People’s Republic of China 4.Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, People’s Republic of China 5.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, People’s Republic of China 6.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China
推荐引用方式 GB/T 7714	Tang JJ,Zhang L,Jiang LP,et al. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation[J]. TETRAHEDRON,2014,70(46):8852-8857.
APA	Tang JJ.,Zhang L.,Jiang LP.,Di L.,Yan YM.,...&Cheng YX[*].(2014).Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation.TETRAHEDRON,70(46),8852-8857.
MLA	Tang JJ,et al."Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation".TETRAHEDRON 70.46(2014):8852-8857.