Decoding the phosphorylation code in Hedgehog signal  transduction

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 肿瘤信号转导

	Decoding the phosphorylation code in Hedgehog signal transduction
	Chen YB[]1; Jiang J[]2
刊名	CELL RESEARCH
	2013
卷号	23 期号:2 页码:186-200
关键词	Hedgehog Smo Gli signal transduction phosphorylation development cancer
通讯作者	ybchen@mail.kiz.ac.cn ; jin.jiang@utsouthwestern.edu
合作状况	其它
英文摘要	Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis, and its deregulation leads to numerous human disorders including cancer. Binding of Hh to Patched (Ptc), a twelve-transmembrane protein, alleviates its inhibition of Smoothened (Smo), a seven-transmembrane protein related to G-protein-coupled receptors (GPCRs), leading to Smo phosphorylation and activation. Smo acts through intracellular signaling complexes to convert the latent transcription factor Cubitus interruptus (Ci)/Gli from a truncated repressor to a full-length activator, leading to derepression/activation of Hh target genes. Increasing evidence suggests that phosphorylation participates in almost every step in the signal relay from Smo to Ci/Gli, and that differential phosphorylation of several key pathway components may be crucial for translating the Hh morphogen gradient into graded pathway activities. In this review, we focus on the multifaceted roles that phosphorylation plays in Hh signal transduction, and discuss the conservation and difference between Drosophila and mammalian Hh signaling mechanisms.
收录类别	SCI
资助信息	Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW.
语种	英语
公开日期	2013-04-10
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7354]
专题	昆明动物研究所_肿瘤信号转导昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kun- ming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, China 2.Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
推荐引用方式 GB/T 7714	Chen YB[],Jiang J[]. Decoding the phosphorylation code in Hedgehog signal transduction[J]. CELL RESEARCH,2013,23(2):186-200.
APA	Chen YB[],&Jiang J[].(2013).Decoding the phosphorylation code in Hedgehog signal transduction.CELL RESEARCH,23(2),186-200.
MLA	Chen YB[*],et al."Decoding the phosphorylation code in Hedgehog signal transduction".CELL RESEARCH 23.2(2013):186-200.