Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 肿瘤生物学

	Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression
	Nie Z 1,2; Wang CY 3; Liu R[]4; Wang DH[]1; Zhou ZM 4; Chen CS 4
刊名	Acta Biochimica et Biophysica Sinica
	2016
卷号	48 期号:2 页码:194-201
关键词	cancer stem cell PMEPA1 TGF-β
通讯作者	liurong@mail.kiz.ac.cn ; wangdianhuakm@126.com
合作状况	其它
英文摘要	The prostate transmembrane protein, androgen-induced 1 (PMEPA1) has been previously shown to promote solid malignancies in a variety of cancers, but the role and mechanisms of PMEPA1 in breast cancer has not been fully addressed. Here, we found that PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. Furthermore, transforming growth factor-β (TGF-β) treatment was also found to upregulate PMEPA1 expression and the CSC-enriched populations in triple-negative breast cancer cell lines. TGF-β-induced PMEPA1 expression partially contributed to TGF-β-induced breast CSC maintenance. These findings suggest that TGF-β-PMEPA1 axis might provide new diagnosis and therapeutic targets for breast cancer treatment.
收录类别	SCI
资助信息	Thisstudy was supportedby the grants fromthe National Natural Sci- ence Foundation of China (Nos. 81272930, 81322038, 31260208, 81460401, and U1132605), Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medi- cine Research (No. XDA01040406), West Light Foundation of the Chinese Academy of Sciences (to R.L.), and Department of Science and Technology of Yunnan Province-Kunming Medical University (No. 4FB022).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9527]
专题	昆明动物研究所_肿瘤生物学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Pharmaceutical College of Kunming Medical University, Kunming 650500, China 2.Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China 3.Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Nie Z,Wang CY,Liu R[*],et al. Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression[J]. Acta Biochimica et Biophysica Sinica,2016,48(2):194-201.
APA	Nie Z,Wang CY,Liu R[],Wang DH[],Zhou ZM,&Chen CS.(2016).Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression.Acta Biochimica et Biophysica Sinica,48(2),194-201.
MLA	Nie Z,et al."Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression".Acta Biochimica et Biophysica Sinica 48.2(2016):194-201.