Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 脂类代谢与疾病

	Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans
	Ding YH 1; Zou XJ[]2; Jiang X 1; Wu JY 1; Zhang YR 1; Chen D 2; Liang B[]1
刊名	PLOS ONE
	2015
卷号	10 期号:2 页码:e0113815
通讯作者	xiaojuzou@163.com ; liangb@mail.kiz.ac.cn
合作状况	其它
英文摘要	Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator SBP-1, a homologue of sterol regulatory element binding protein (SREBP) and its target stearoyl-CoA desaturase (SCD), a key enzyme in fat biosynthesis, leading to an increased ratio of stearic acid (C18:0) to oleic acid (C18:1n-9), and subsequently decreased fat storage. We also found that both the pharyngeal pumping rate and food uptake of Caenorhaditis elegans decreased with exposure to PTE. Collectively, these results provide an experimental basis for explaining the ability of Pu-erh tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD, thereby reducing fat storage.
收录类别	SCI
资助信息	This work was supported by National Natural Science Foundation of China (NSFC) 31160216 to XJ Zou and 31171134 to B Liang; Yunnan Natural Science Foundation 2011FZ179 and Kunming University Science Project YJL11018 to XJ Zou; and Yunnan Provincial Science and Technology Department 2014HB022.
语种	英语
WOS记录号	WOS:000349444900006
公开日期	2015-03-20
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8282]
专题	昆明动物研究所_脂类代谢与疾病昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China 2.Department of Life Science and Technology, Key Laboratory of Special Biological Resource Development and Utilization of University in Yunnan Province, Kunming University, Kunming, 650214, China
推荐引用方式 GB/T 7714	Ding YH,Zou XJ[*],Jiang X,et al. Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans[J]. PLOS ONE,2015,10(2):e0113815.
APA	Ding YH.,Zou XJ[].,Jiang X.,Wu JY.,Zhang YR.,...&Liang B[].(2015).Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans.PLOS ONE,10(2),e0113815.
MLA	Ding YH,et al."Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans".PLOS ONE 10.2(2015):e0113815.