Morphine withdrawal modifies antinociceptive effects of acute morphine in rats

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Morphine withdrawal modifies antinociceptive effects of acute morphine in rats
	Dong ZF 1,2; Mao RR 1,2; Han HL 1,2; Cao J[]1,2; Xu L[]1,2,3
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2006
卷号	346 期号:2 页码:578-582
关键词	glucocorticoid receptors glucocorticoids withdrawal antinociceptive effect stress RU38486
通讯作者	juncao@vip.163.com ; Ixu@vip.163.com
英文摘要	Repeated opioid use is known to cause tolerance of antinociceptive effects. Whether opioid abstinence modifies antinociceptive effects is unknown. Here we reported that morphine withdrawal for 18 h and 4 days after repeated morphine treatment largely reduced tail-flick latencies compared with control, while the rats showed severe withdrawal syndromes. However, the latencies and withdrawal syndromes were restored to control level at 20 days withdrawal. Similarly, antinociceptive effects of acute morphine were decreased at 18 h and further decreased at 4 days but restored to control level at 20 days withdrawal. Behavioral stress that was given to the rats at 18 It withdrawal further reduced tail-flick latencies and antinociceptive effects. Conversely, the glucocorticoid receptor antagonist RU38486 increased tail-flick latencies and antinociceptive effects at 4 days withdrawal. These results suggest that morphine withdrawal could evoke behavioral stress to modify antinociceptive effects, implicating a significant influence of opioid abstinence on chronic pain treatment.
收录类别	SCI
资助信息	This work was supported by the grants from National Natural Science Foundation of China (30470549 and 30530250 to L.X.; 30500150 to J.C.), and National Basic Research 973 Program
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10877]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China 3.Mental Health Institute, The 2nd Hospital of Central South University, Changsha 410011, PR China
推荐引用方式 GB/T 7714	Dong ZF,Mao RR,Han HL,et al. Morphine withdrawal modifies antinociceptive effects of acute morphine in rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,346(2):578-582.
APA	Dong ZF,Mao RR,Han HL,Cao J[],&Xu L[].(2006).Morphine withdrawal modifies antinociceptive effects of acute morphine in rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,346(2),578-582.
MLA	Dong ZF,et al."Morphine withdrawal modifies antinociceptive effects of acute morphine in rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 346.2(2006):578-582.