Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders
	Zhang Y 1; Mao RR 2; Chen ZF 1; Tian M 2; Tong DL 1; Gao ZR 1; Huang M 1; Li X 1; Xu X 5; Zhou WH 4
刊名	MOLECULAR BRAIN
	2014
卷号	7 期号:X 页码:e11
关键词	Deep-brain magnetic stimulation Adult hippocampal neurogenesis Long-term potentiation Depression MeCP2 Rett syndrome
通讯作者	zqiu@ion.ac.cn ; lxu@vip.163.com
合作状况	其它
英文摘要	Background: Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood. Results: Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically. Conclusions: Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Program of China (2011CBA00400 to Z.Q., 2013CB835103 and 2009CB941302 to L.X.), CAS Hundreds of Talents Program (Z.Q.), Strategic Priority Research Program of Chinese Academy of Sciences, Grant No.XDB02050400 (Z.Q.) and the National Natural Science Foundation of China (U1032605 to L.X, 31100786 to R. M.).
语种	英语
WOS记录号	WOS:000334877500002
公开日期	2015-06-10
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8360]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 3.School of Electrical and Automation Engineering, Tianjin University, Tianjin, China 4.Departments of Neonatology, Children’s Hospital of Fudan University, Shanghai, China 5.Department of Child Healthcare, Children’s Hospital of Fudan University, Shanghai, China
推荐引用方式 GB/T 7714	Zhang Y,Mao RR,Chen ZF,et al. Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders[J]. MOLECULAR BRAIN,2014,7(X):e11.
APA	Zhang Y.,Mao RR.,Chen ZF.,Tian M.,Tong DL.,...&Qiu ZL[*].(2014).Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders.MOLECULAR BRAIN,7(X),e11.
MLA	Zhang Y,et al."Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders".MOLECULAR BRAIN 7.X(2014):e11.