Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging
	Cheng YQ 1; Xu J 2; Yu HJ 3; Nie BB 4; Li N 1; Luo CR 3; Li HJ 3; Liu F 1; Bai Y 1; Shan BC 4
刊名	PLOS ONE
	2014
卷号	9 期号:11 页码:e112307
通讯作者	lxu@vip.163.com ; xfxu2004@sina.com
合作状况	其它
英文摘要	Background: Due to a lack of evidence, there is no consistent age of onset to define early onset (EO) versus later onset (LO) major depressive disorder (MDD). Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used to study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities of which might facilitate the delineation of EO versus LO MDD. Method: In this study, 61 pairs of untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged 18-45 years old received DTI scans. The voxel-based analysis method (VBM), classification analysis, using the Statistical Package for the Social Sciences (SPSS), and regression analyses were used to determine abnormal FA clusters and their correlations with age of onset and clinical symptoms. Results: Classification analysis suggested in the best model that there were two subgroups of MDD patients, delineated by an age of onset of 30 years old, by which MDD patients could be divided into EO (18-29 years old) and LO (30-45 years old) groups. LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms. Conclusion: Specific abnormalities of the brain circuitry in EO vs. LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms. This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.
收录类别	SCI
资助信息	This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167).
语种	英语
WOS记录号	WOS:000347709300051
公开日期	2015-02-06
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8253]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, PR China 2.Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, PR China 3.Magnetic Resonance Imaging Center, the First Hospital of Kunming City, Kunming, PR China 4.Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, PR Chin 5.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, PR China
推荐引用方式 GB/T 7714	Cheng YQ,Xu J,Yu HJ,et al. Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging[J]. PLOS ONE,2014,9(11):e112307.
APA	Cheng YQ.,Xu J.,Yu HJ.,Nie BB.,Li N.,...&Xu XF[*].(2014).Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging.PLOS ONE,9(11),e112307.
MLA	Cheng YQ,et al."Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging".PLOS ONE 9.11(2014):e112307.