Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region

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	Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region
	Xu J 1,2; Cheng YQ 3; Chen B 4; Bai R 2; Li SA 2; Xu XF 3; Xu L 5; Wen JF 4; Lu ZP 2; Zeng XF[*]1
刊名	LUPUS
	2013
卷号	22 期号:10 页码:1001-1010
关键词	ystemic lupus erythematosus depression DNA methylation serotonin transporter-linked polymorphism
通讯作者	zxfpumch@163.com
合作状况	其它
英文摘要	A higher prevalence of depression in systemic lupus erythematosus (SLE) patients has been reported, though the mechanism underlying this phenomenon remains unclear. The present study was conducted to explore whether the polymorphism and methylation status of the serotonin transporter gene (5HTT) promoter region (PR-5HTT) contribute to depression in SLE patients from both genetic and epigenetic perspectives. In this study, 96 SLE patients and 96 healthy controls (HCs) were recruited. Depression levels of all subjects were evaluated using the Hamilton Depression Rating Scale (HDRS). The serotonin transporter-linked polymorphism (5HTTLPR) and the DNA methylation status of PR-5HTT were detected in peripheral lymphocytes of SLE patients and HCs. The differences in 5HTTLPR and DNA methylation of PR-5HTT between SLEs and HCs were compared. In SLE patients, the frequencies of short allele (S) and SS genotype of 5HTTLPR were higher in depressive SLE (SLE-D) patients than in non-depressive SLE (SLE-ND) patients. The mean HDRS score of SS homozygote patients was higher than that of patients with SL/LL genotypes. Conversely, PR-5HTT was hypomethylated in HCs as well as SLE patients. There was no difference in the methylation status between HCs and SLEs. Thus, the functional expression of PR-5HTT may be primarily regulated by gene polymorphism and not by DNA methylation. The risk allele of 5HTTLPR appears to be a major contributor to depression in SLE patients.
收录类别	SCI
资助信息	This work is supported by grants from the Supporting Program of the ‘‘Eleventh Five-year Plan’’ for Science and Technology Research of China (2008BAI59B02, 2008BAI59B03), the National High Technology Research and Development Program of China (863 Program) (2012AA02A513), the National Natural Science Foundation of China (81101005, 81160379, and 81160171); United Funding of Yunnan Provincial Science and Technology Department and Kunming Medical University (2011FB167); The Funding of Yunnan Provincial Health Science and Technology Plan (2010NS016, 2011WS008), and the Funding of Yunnan Provincial Public Health for Academic Leadership (D-201218, D-201239).
语种	法语
WOS记录号	WOS:000323313100004
公开日期	2013-09-13
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7626]
专题	昆明动物研究所_真核细胞进化基因组昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_学习记忆的分子神经机制
作者单位	1.Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China 2.Department of Rheumatology and Immunology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China 3.Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, PR China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China 5.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Xu J,Cheng YQ,Chen B,et al. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region[J]. LUPUS,2013,22(10):1001-1010.
APA	Xu J.,Cheng YQ.,Chen B.,Bai R.,Li SA.,...&Zeng XF[*].(2013).Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region.LUPUS,22(10),1001-1010.
MLA	Xu J,et al."Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region".LUPUS 22.10(2013):1001-1010.