Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD | |
Han J1; Kesner P2; Metna-Laurent M3,4; Duan TT5,6; Xu L5; Georges F4,7; Koehl M3,4; Abrous DN3,4; Mendizabal-Zubiaga J8; Grande P8 | |
刊名 | CELL
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2012 | |
卷号 | 148期号:5页码:1039-1050 |
其他题名 | giovanni.marsicano@inserm.fr; xia.zhang@rohcg.on.ca |
通讯作者 | giovanni.marsicano@inserm.fr |
合作状况 | 其它 |
英文摘要 | Impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its underlying mechanisms are presently unknown. Here, we demonstrate that the impairment of spatial working memory (SWM) and in vivo long-term depression (LTD) of synaptic strength at hippocampal CA3-CA1 synapses, induced by an acute exposure of exogenous cannabinoids, is fully abolished in conditional mutant mice lacking type-1 cannabinoid receptors (CB1R) in brain astroglial cells but is conserved in mice lacking CB1R in glutamatergic or GABAergic neurons. Blockade of neuronal glutamate N-methyl-D-aspartate receptors (NMDAR) and of synaptic trafficking of glutamate alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid receptors (AMPAR) also abolishes cannabinoid effects on SWM and LTD induction and expression. We conclude that the impairment of working memory by marijuana and cannabinoids is due to the activation of astroglial CB1R and is associated with astroglia-dependent hippocampal LTD in vivo |
收录类别 | SCI |
资助信息 | Support from China-Canada Joint Research grant (to L. Xu and X.Z.), The Basque Country Government grant (GIC07/70-IT-432-07, to P.G.), Ministerio de Ciencia e Innovacio ´n (SAF2009- 07065, to P.G.), Red de Trastornos Adictivos, RETICS, Instituto de Salud Car- los III, MICINN (RD07/0001/2001, to P.G.), NIH grants (DA024741, to Q.L.; NS38077, to G.B.), grants from National Natural Science Foundation of China (NNSFC, 30725019, 81030021, to W.W.), 973 Progress (2009CB941300, to L. Xu), NNSFC for distinguished young scholars (30725039, to L.X.), Major Program of NNSFC (30930091, to L.X.), National High Technology Research and Development Program of China (863, 2007AA02Z310, to W.R.), INSERM/Avenir (to G.M.), INSERM (to D.N.A.), European Research Council (ERC-2010-StG-260515, to G.M.), EU-FP7 (REPROBESITY, HEALTH-F2- 2008-223713, to G.M.), Fondation pour la Recherche Medicale (to G.M.), Region Aquitaine (to M.M.-L., G.M., and D.N.A.), Canadian Institutes of Health Research (to X.Z.), Natural Sciences and Engineering Research Council of Canada (to X.Z.), Cheung Kong Scholar (Chang Jiang Scholar) Award (to X.Z.), and Canadian Foundation for Innovation (to X.Z.). |
语种 | 英语 |
WOS记录号 | WOS:000300985000022 |
公开日期 | 2012-04-20 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.42:8088/handle/152453/6925] ![]() |
专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
作者单位 | 1.College of Life Sciences and Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xian 710062, China 2.University of Ottawa Institute of Mental Health Research at The Royal, Department of Psychiatry, and Department of Cellular and Molecular Medicine, Ottawa K1Z 7K4, Canada 3.INSERM, Neurocentre Magendie 4.University of Bordeaux, Neurocentre Magendie Physiopathologie de la Plasticite ´ Neuronale, U862, F-33000 Bordeaux, France 5.Key Lab of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China 6.School of Life Sciences, University of Science and Technology of China, Hefei 230027, China 7.CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux 33000, France 8.Department of Neurosciences, Faculty of Medicine and Dentistry, Basque Country University, Leioa 48940, Spain 9.Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA 10.Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA |
推荐引用方式 GB/T 7714 | Han J,Kesner P,Metna-Laurent M,et al. Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD[J]. CELL,2012,148(5):1039-1050. |
APA | Han J.,Kesner P.,Metna-Laurent M.,Duan TT.,Xu L.,...&Zhang X[*].(2012).Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD.CELL,148(5),1039-1050. |
MLA | Han J,et al."Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD".CELL 148.5(2012):1039-1050. |
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