Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species | |
Su J1; Chen X1; Huang Y1; Li W1; Li J1; Cao K1; Cao G1; Zhang L2; Li F1; Roberts AI2 | |
刊名 | CELL DEATH AND DIFFERENTIATION
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2014 | |
卷号 | 21期号:3页码:388-396 |
关键词 | mesenchymal stem cells indoleamine 2 inducible nitric oxide synthase 3-dioxygenase immunosuppression mammalian phylogeny |
通讯作者 | yingwang@sibs.ac.cn ; yufangshi@sibs.ac.cn |
合作状况 | 其它 |
英文摘要 | Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We have reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) in human and inducible nitric oxide synthase (iNOS) in mouse. In the present study, we isolated MSCs from several mammalian species, each of a different genus, and investigated the involvement of IDO and iNOS during MSC-mediated immunosuppression. The characterization of MSCs from different species was by adherence to tissue culture plastic, morphology, specific marker expression, and differentiation potential. On the basis of the inducibility of IDO and iNOS by inflammatory cytokines in MSCs, the tested mammalian species fall into two distinct groups: IDO utilizers and iNOS utilizers. MSCs from monkey, pig, and human employ IDO to suppress immune responses, whereas MSCs from mouse, rat, rabbit, and hamster utilize iNOS. Interestingly, based on the limited number of species tested, the iNOS-utilizing species all belong to the phylogenetic clade, Glires. Although the evolutionary significance of this divergence is not known, we believe that this study provides critical guidance for choosing appropriate animal models for preclinical studies of MSCs. |
收录类别 | SCI |
资助信息 | This work was supported by grants from the Ministry of Science and Technology of China (2010CB945600, 2011DFA30630), Scientific Innovation Project of the Chinese Academy of Sciences (XDA01040107), Inter- national Cooperation and Exchanges NSFC (31010103908), Shanghai Municipal Key Projects of Basic Research (12JC1409200). |
语种 | 英语 |
WOS记录号 | WOS:000331274500006 |
公开日期 | 2014-03-24 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.42:8088/handle/152453/7824] ![]() |
专题 | 昆明动物研究所_生殖与发育生物学 |
作者单位 | 1.Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong UniversitySchool of Medicine, 225 SouthChongqing Road, Shanghai 200025, China 2.Child Health Instituteof New Jersey, University of Medicine and Dentistry ofNew Jersey-Robert Wood Johnson Medical School, 89 French Street, NJ 08901, USA 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
推荐引用方式 GB/T 7714 | Su J,Chen X,Huang Y,et al. Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species[J]. CELL DEATH AND DIFFERENTIATION,2014,21(3):388-396. |
APA | Su J.,Chen X.,Huang Y.,Li W.,Li J.,...&Shi Y[*].(2014).Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species.CELL DEATH AND DIFFERENTIATION,21(3),388-396. |
MLA | Su J,et al."Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species".CELL DEATH AND DIFFERENTIATION 21.3(2014):388-396. |
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