Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice

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	Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice
	Liu Q 1,3; Li A 1; Gong L 1,3; Zhang L 3,4; Wu N 1; Xu FQ[*]1,2
刊名	NEUROSCIENCE LETTERS
	2013
卷号	545 期号:X 页码:81-85
关键词	Alzheimer's disease Olfactory bulb Coherence Beta oscillation Awake animals
通讯作者	fuqiang.xu@wipm.ac.cn
合作状况	其它
英文摘要	Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by cell and synapse losses and the ensued network disconnections. Olfactory impairment is common and occurs early in AD patients, suggesting its potential role in the early diagnosis of AD. However, the functional connectivity of the olfactory system in AD has received little attention. Using local field potentials symmetrically recorded from the two olfactory bulbs in awake mice, we found that in AD model mice with robust amyloid-beta burden, the coherence between the two bulbs for spontaneous activities was significantly lower in all of the four frequency bands (theta, beta, low and high gamma: 2-12, 15-35, 35-65 and 65-100 Hz, respectively). Moreover, the coherence for odor-evoked activities was also lower, particularly in the beta band, when compared to their wild-type littermates. These results demonstrate that the inter-bulbar functional connectivity is impaired in AD mice, indicating a failure of brain activation in beta-related functions, which might be of importance in the diagnosis of AD.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foun- dation of China (NSFC, 91132307/H09, 31171061/C090208 and 20921004), the Chinese Academy of Sciences (XDB02050500), the Ministry of Science and Technology of China (2012BAI23B02) to F. Xu and the NSFC (31100799) to Anan Li.
语种	英语
WOS记录号	WOS:000321031600016
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7600]
专题	昆明动物研究所_神经系统编码
作者单位	1.Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences/State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan 430071, China 2.Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China 3.Graduate University of Chinese Academy of Sciences, Beijing 100049, Chin 4.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Liu Q,Li A,Gong L,et al. Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice[J]. NEUROSCIENCE LETTERS,2013,545(X):81-85.
APA	Liu Q,Li A,Gong L,Zhang L,Wu N,&Xu FQ[*].(2013).Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice.NEUROSCIENCE LETTERS,545(X),81-85.
MLA	Liu Q,et al."Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice".NEUROSCIENCE LETTERS 545.X(2013):81-85.