Protein kinase M zeta and the maintenance of long-term memory

	Protein kinase M zeta and the maintenance of long-term memory
	Zhang Y 1,2; Zong W 3; Zhang L 1; Ma YY 1,4; Wang JH[*]1
刊名	NEUROCHEMISTRY INTERNATIONAL
	2016
卷号	99 期号:X 页码:215-220
关键词	Protein kinase M zeta (PKM zeta) Maintenance of long-term memory Zeta inhibitory peptide (ZIP)
通讯作者	wjh16@hotmail.com
合作状况	其它
英文摘要	Although various molecules have been found to mediate the processes of memory acquisition and consolidation, the molecular mechanism to maintain memory still remains elusive. In recent years, a molecular pathway focusing on protein kinase M zeta (PKM zeta) has become of interest to researchers because of its potential role in long-term memory maintenance. PKM zeta is an isoform of protein kinase C (PKC) and has a related structure that influences its function in maintaining memory. Considerable evidence has been gathered on PKM zeta activity, including loss of function studies using PKM zeta inhibitors, such as PKM zeta inhibitory peptide (ZIP), suggesting PKM zeta plays an important role in long-term memory maintenance. This review provides an overview of the role of PKM zeta in long-term memory and outlines the molecular structure of PKM zeta, the molecular mechanism of PKM zeta in long-term memory maintenance and future directions of PKM zeta research.
收录类别	SCI
资助信息	. This work was supported by the National Science Foundation of China (NSFC 31271168, 31571109, Chinese-Finnish Joint Project 813111172) and Yunnan Key Program of Science and Technology (2014FC005).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10757]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Shandong Association for Science & Technology, China 3.Honghe Health Vocational College, Yunnan, China 4.Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
推荐引用方式 GB/T 7714	Zhang Y,Zong W,Zhang L,et al. Protein kinase M zeta and the maintenance of long-term memory[J]. NEUROCHEMISTRY INTERNATIONAL,2016,99(X):215-220.
APA	Zhang Y,Zong W,Zhang L,Ma YY,&Wang JH[*].(2016).Protein kinase M zeta and the maintenance of long-term memory.NEUROCHEMISTRY INTERNATIONAL,99(X),215-220.
MLA	Zhang Y,et al."Protein kinase M zeta and the maintenance of long-term memory".NEUROCHEMISTRY INTERNATIONAL 99.X(2016):215-220.