Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference

	Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference
	Yan T 1,2; Rizak JD 1,2; Wang JH 1; Yang SC 1; Ma YY 1,3,4; Hu XT[*]1,3,4
刊名	FRONTIERS IN BEHAVIORAL NEUROSCIENCE
	2015
卷号	9 期号:X 页码:e273
关键词	dopamine morphine place preference reward rhesus monkey
通讯作者	xthu@mail.kiz.ac.cn
合作状况	其它
英文摘要	It is well known that dopamine (DA) is critical for reward, but the precise role of DA in reward remains uncertain. The aim of this study was to determine what percentage of dopaminergic neurons in the primate brain is required for the expression of conditioned reward by measuring the performance of DA-deficient rhesus monkeys in a morphine-induced conditioned place preference (CPP) paradigm. Animals with mild Parkinsonian symptoms successfully developed and retained a morphine preference that was equivalent to control monkeys. However, these monkeys could not maintain the preference as well as controls when they retained severe Parkinsonian symptoms. On the other hand, monkeys initially in a severe Parkinsonian state developed a preference for morphine, but this preference was weaker than that of the controls. Histological results showed that the loss of dopaminergic neurons in monkeys that had severe Parkinsonian symptoms was about 80% in comparison to the control monkeys. All these data suggest that a severely impaired DA system alters rewarding-seeking behavior in non-human primates.
收录类别	SCI
资助信息	This research was supported by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503 and 2012CBA01304), the Strategic Priority Research Program of the Chinese Academy of Science (XDB02020000), the Key Program of the Chinese Academy of Sciences (KZCC-EW- 103-2), the Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), the National Natural Science Foundation of China (81471312, 31271167 and 81271495), the Yunnan Provincial Project to attract one hundred exceptional talents from overseas, and the National High-tech R&D Program of China (863 Program 2012AA020701).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9474]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Yan T,Rizak JD,Wang JH,et al. Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9(X):e273.
APA	Yan T,Rizak JD,Wang JH,Yang SC,Ma YY,&Hu XT[*].(2015).Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9(X),e273.
MLA	Yan T,et al."Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9.X(2015):e273.