Acute Morphine Treatments Alleviate Tremor in 1Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Monkeys

	Acute Morphine Treatments Alleviate Tremor in 1Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Monkeys
	Yan T 1,4; Rizak JD 1,4; Yang SC 1; Li H 1,4; Huang BH 1,4; Ma YY[]1,2,3; Hu XT[]1,2,3
刊名	PLOS ONE
	2014
卷号	9 期号:2 页码:e88404
通讯作者	yuanma0716@vip.sina.com ; xthu@mail.kiz.ac.cn
合作状况	其它
英文摘要	Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder associated with decreased striatal dopamine levels. Morphine has been found to elevate dopamine levels, which indicates a potential therapeutic effect in PD treatment that has not been investigated previously. To evaluate this hypothesis, an investigation of the acute effects of morphine on PD symptoms was carried out in male rhesus PD monkeys that had been induced with MPTP. All MPTP induced monkeys displayed progressive and irreversible PD motor symptoms. The behavioral response of these animals to morphine and L-Dopa were quantified with the Kurlan scale. It was found that L-Dopa alleviated bradykinesia, but did not significantly improve tremor. In contrast, acute morphine alleviated tremor significantly. These results suggested that, compared to L-Dopa, morphine has different therapeutic effects in PD therapy and may act through different biological mechanisms to alleviate PD symptoms.
收录类别	SCI
资助信息	This research was supported by the Strategic Priority Research Program of the Chinese Academy of Science XDB02020000, 973 program 2012CB825500, 2012CBA01304 and 2011CB707800, the 863 program 2012AA020701, KSCX2-EW-J-23 and KSCX2-EW-R-11, the National Science Foundation of China NSFC 91332120, 31271167, 31070963, 31271168, 81271495 and 31070965.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9286]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China 2.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China 3.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China 4.University of Chinese Academy of Science, Beijing, China
推荐引用方式 GB/T 7714	Yan T,Rizak JD,Yang SC,et al. Acute Morphine Treatments Alleviate Tremor in 1Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Monkeys[J]. PLOS ONE,2014,9(2):e88404.
APA	Yan T.,Rizak JD.,Yang SC.,Li H.,Huang BH.,...&Hu XT[*].(2014).Acute Morphine Treatments Alleviate Tremor in 1Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Monkeys.PLOS ONE,9(2),e88404.
MLA	Yan T,et al."Acute Morphine Treatments Alleviate Tremor in 1Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Monkeys".PLOS ONE 9.2(2014):e88404.